Applied Biochemistry and Biotechnology

, Volume 172, Issue 8, pp 3761–3775 | Cite as

Self-Tuning GMV Control of Glucose Concentration in Fed-Batch Baker’s Yeast Production

  • Zeynep Yilmazer HititEmail author
  • Havva Boyacioglu
  • Baran Ozyurt
  • Suna Ertunc
  • Hale Hapoglu
  • Bulent Akay


A detailed system identification procedure and self-tuning generalized minimum variance (STGMV) control of glucose concentration during the aerobic fed-batch yeast growth were realized. In order to determine the best values of the forgetting factor (λ), initial value of the covariance matrix (α), and order of the Auto-Regressive Moving Average with eXogenous (ARMAX) model (n a, n b), transient response data obtained from the real process wereutilized. Glucose flow rate was adjusted according to the STGMV control algorithm coded in Visual Basic in an online computer connected to the system. Conventional PID algorithm was also implemented for the control of the glucose concentration in aerobic fed-batch yeast cultivation. Controller performances were examined by evaluating the integrals of squared errors (ISEs) at constant and random set point profiles. Also, batch cultivation was performed, and microorganism concentration at the end of the batch run was compared with the fed-batch cultivation case. From the system identification step, the best parameter estimation was accomplished with the values λ = 0.9, α = 1,000 and n a = 3, n b = 2. Theoretical control studies show that the STGMV control system was successful at both constant and random glucose concentration set profiles. In addition, random effects given to the set point, STGMV control algorithm were performed successfully in experimental study.


Self-tuning generalized minimum variance control (STGMV) Bioreactor Saccharomyces cerevisiae Baker’s yeast System identification Glucose concentration control 


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Zeynep Yilmazer Hitit
    • 1
    Email author
  • Havva Boyacioglu
    • 1
  • Baran Ozyurt
    • 1
  • Suna Ertunc
    • 1
  • Hale Hapoglu
    • 1
  • Bulent Akay
    • 1
  1. 1.Faculty of Engineering, Department of Chemical EngineeringAnkara UniversityAnkaraTurkey

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