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Emerging Approaches in Fermentative Production of Statins

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Abstract

Microbial metabolites have many important applications in pharmaceutical and health-care industry. The products of microbial origin are usually produced by submerged fermentation. The solid-state fermentation represents an alternative mode of fermentation, which is increasingly being employed as an alternative to submerged fermentation for metabolite production. The prospect of producing high-value product using low-value raw material offers a substantial premium to switch to these technologies. The cost of statins being one major factor, solid-state fermentation with agro-industrial residues as carbon, nitrogen and support matrix, promises to substantially lower the cost of production. Hence, newer approaches are required to exploit the agro-industrial residues for statin production. The development of these technologies offers an opportunity to exploit low-cost substrates without substantial investment in newer production methodologies. The emerging evidence of beneficial effect of statins in applications other than lipid lowering such as in Alzheimer disease, HIV, age-related dementia, and cancer chemotherapy makes it very important to develop methods for economic production of statins.

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Authors and Affiliations

  1. Microbiology Division, CSIR-Central Drug Research Institute (CDRI), B 10/1, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow, 226 031, India

    Sudheer Kumar Singh

  2. Biotechnology Division, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Trivandrum, 695 019, India

    Ashok Pandey

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  1. Sudheer Kumar Singh
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Correspondence to Sudheer Kumar Singh.

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Singh, S.K., Pandey, A. Emerging Approaches in Fermentative Production of Statins. Appl Biochem Biotechnol 171, 927–938 (2013). https://doi.org/10.1007/s12010-013-0400-2

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