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Synthesis and Biological Evaluation of a Novel Series of Chalcones Incorporated Pyrazole Moiety as Anticancer and Antimicrobial Agents

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Abstract

A newly synthesized series of chalcone derivatives containing pyrazole rings were synthesized and evaluated for their cytotoxic activities in vitro against several human cancer cell lines. Most of the prepared compounds showed potential cytotoxicity against human breast cancer cell lines MCF-7, HEPG-2, and HCT-116. Also the compounds were evaluated as antimicrobial agents. The three compounds 3, 4, and 5 were proved to be better anticancer agents than the positive standard doxorubicin with IC50 values (4.7, 4.4, and 3.9 μg/ml) against the same human cancer cell lines, whereas compounds 5 and 6 showed the most active antimicrobial compounds in comparison to the other chalcones.

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Authors and Affiliations

  1. Department of Chemistry (Biochemistry Branch), Faculty of Science, Cairo University, Giza, Egypt

    Magda F. Mohamed & Mervat S. Mohamed

  2. Department of Cancer Biology, National Cancer Institute, Cairo University, Giza, Egypt

    Samia A. Shouman

  3. Department of Zoology, Faculty of Science, Cairo University, Giza, Egypt

    Mohamed M. Fathi

  4. Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt

    Ismail Abdelshafy Abdelhamid

Authors
  1. Magda F. Mohamed
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  2. Mervat S. Mohamed
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  3. Samia A. Shouman
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  4. Mohamed M. Fathi
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  5. Ismail Abdelshafy Abdelhamid
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Correspondence to Ismail Abdelshafy Abdelhamid.

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Mohamed, M.F., Mohamed, M.S., Shouman, S.A. et al. Synthesis and Biological Evaluation of a Novel Series of Chalcones Incorporated Pyrazole Moiety as Anticancer and Antimicrobial Agents. Appl Biochem Biotechnol 168, 1153–1162 (2012). https://doi.org/10.1007/s12010-012-9848-8

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  • DOI: https://doi.org/10.1007/s12010-012-9848-8

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