Applied Biochemistry and Biotechnology

, Volume 166, Issue 4, pp 830–838 | Cite as

Investigation on Ultrasound-Assisted Extraction and Separation of Enduracidin from Streptomyces sp. NJWGY3665

  • Yonghong HuEmail author
  • Wenge Yang
  • Wenqian Wan
  • Fei Shen
  • Ziyu Lei
  • Dandan Wang


Ultrasound-assisted extraction of enduracidin from Streptomyces sp. NJWGY3665 was studied. The effects of various factors on the yield of target components were investigated. The results showed that the extraction by ultrasound-assisted extraction is four times faster than those by conventional solvent extraction. The results also indicated that fast extraction rate was obtained in the first 30 min, and the maximum yield was obtained at the power of 150 W. The effects of other factors such as different solvents, solvent concentration, solvent to solid ratio, and extraction batches on the field were also discussed. The optimum conditions were found at solvent of methanol, time of 30 min, power of 150 W, pH of 7.0, solvent to solid ratio of 50 ml/g, solvent concentration of 70% and extraction batches of four times.


Enduracidin Streptomyces Ultrasound-assisted extraction 



This research work was supported by Natural Science Basic Research Program of Higher Education in Jiangsu Province (08KJA530002), Program of Six Talent Tops Foundation of Jiangsu Province (no. 2009118), and Jiangsu Engineering Technology Research Center of Polypeptide Pharmaceutical.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Yonghong Hu
    • 1
    Email author
  • Wenge Yang
    • 1
  • Wenqian Wan
    • 1
  • Fei Shen
    • 1
  • Ziyu Lei
    • 1
  • Dandan Wang
    • 1
  1. 1.College of Biotechnology and Pharmaceutical EngineeringNanjing University of TechnologyNanjingPeople’s Republic of China

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