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Conserved Domains, Conserved Residues, and Surface Cavities of C-reactive Protein (CRP)

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Abstract

C-reactive protein (CRP) is a highly conserved plasma protein belonging to pentraxins, a superfamily which has significant proinflammatory role. Therefore, CRP can be a good target for drug discovery to prevent disease pathogenesis, especially cardioprotection in acute myocardial infarction and neuroprotection in stroke. Hence, the knowledge of the structure of CRP is very important. In this paper, we have demonstrated three-dimensional structure, conserved domains, and surface structure of human CRP with the help of bioinformatics analysis. We have also depicted that evolutionary relationship of CRP exists among the different species. Simultaneously, WebLogo has been generated to know the more conserved part of this medically important protein.

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Acknowledgment

We would like to thank the senior management of VIT University (Vellore, India) for their kind support and encouragement for our research work.

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Authors and Affiliations

  1. Medical Biotechnology Division, School of Bio-Sciences and Technology, VIT University, Vellore, India

    Suggula Varun Kumar, Roshini Kulampurathu Ravunny & Chiranjib Chakraborty

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  1. Suggula Varun Kumar
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  2. Roshini Kulampurathu Ravunny
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  3. Chiranjib Chakraborty
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Correspondence to Chiranjib Chakraborty.

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All authors contributed equally to this article.

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Kumar, S.V., Ravunny, R.K. & Chakraborty, C. Conserved Domains, Conserved Residues, and Surface Cavities of C-reactive Protein (CRP). Appl Biochem Biotechnol 165, 497–505 (2011). https://doi.org/10.1007/s12010-011-9270-7

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  • DOI: https://doi.org/10.1007/s12010-011-9270-7

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