Abstract
Atherosclerosis is a chronic inflammatory disease of multiple etiologies. It is associated with the accumulation of oxidized lipids in arterial lesions leading to coronary heart disease. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (commonly known as statins) are widely used in cardiovascular disease prevention to lower the cholesterol. The antioxidant activity of HMG-CoA reductase inhibitors was studied by lipid peroxidation inhibition assay, DPPH, and hydroxyl radical scavenging-activity methods. The lovastatin (93%) and simvastatin (96%) showed significant action of lipid peroxidation inhibition compared to other HMG-CoA reductase inhibitors. The DPPH radical and hydroxyl radical scavenging activity of simvastatin was 38% and 33%, respectively. The oxidative modification of serum lipid due to reactive oxygen species causes atherosclerosis. This study revealed the importance of lovastatin and simvastatin to prevent oxidative stress-related cardiovascular diseases.
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Acknowledgement
H. P. Mohan-Kumari acknowledge CSIR, New-Delhi and Dr. V. Prakash, Director, CFTRI, Mysore for providing research fellowship and facility to carry out this work respectively. V. Gaonkar and S. Keni thank Dr. Satish R. Shetye, Director, NIO, Dona Paula, Goa for providing the facility to carry out this work.
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Puttananjaiah, MK.H., Dhale, M.A., Gaonkar, V. et al. Statins: 3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) Reductase Inhibitors Demonstrate Anti-Atherosclerotic Character due to Their Antioxidant Capacity. Appl Biochem Biotechnol 163, 215–222 (2011). https://doi.org/10.1007/s12010-010-9031-z
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DOI: https://doi.org/10.1007/s12010-010-9031-z