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Application of Quartz Crystal Nanobalance for Simultaneous Determination of Vanillylmandelic and Homovanillic Acids by a Net Analyte Signal-Based Method

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Abstract

Homovanillic acid (HVA) and vanillylmandelic acid (VMA) were selectively determined by quartz crystal nanobalance sensor in conjunction with net analyte signal (NAS)-based method called HLA/GO. An orthogonal design was applied for the formation of calibration and prediction sets including HVA, VMA, and some common and structurally similar urine compounds. The selection of the optimal time range involved the calculation of the NAS regression plot in any considered time window for each test sample. The searching of a region with maximum linearity of NAS regression plot (minimum error indicator) and minimum of predicted error sum of squares value was carried out by applying a moving window strategy. Based on the obtained results, the differences on the adsorption profiles in the time range between 1 and 300 s were used to determine mixtures of compounds by HLA/GO method. Several figures of merit like selectivity, sensitivity, analytical sensitivity, and limit of detection were calculated for both compounds. The results showed that the method was successfully applied for the determination of VMA and HVA.

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Acknowledgments

We are most grateful for the financial supports of this research project by the University of Tabriz and the Research Center for Pharmaceutical Nanotechnology (RCPN) of Tabriz University of Medical Science.

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Authors and Affiliations

  1. Department of Natural Sciences, Faculty of Animal Sciences, University of Tabriz, Tabriz, Iran

    Maryam Shojaei

  2. Polymer Research Technology Laboratory, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran

    Abdolreza Mirmohseni & Maryam Farbodi

  3. Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran

    Yadollah Omidi

Authors
  1. Maryam Shojaei
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  2. Abdolreza Mirmohseni
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  3. Yadollah Omidi
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  4. Maryam Farbodi
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Correspondence to Maryam Shojaei.

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Shojaei, M., Mirmohseni, A., Omidi, Y. et al. Application of Quartz Crystal Nanobalance for Simultaneous Determination of Vanillylmandelic and Homovanillic Acids by a Net Analyte Signal-Based Method. Appl Biochem Biotechnol 159, 54–64 (2009). https://doi.org/10.1007/s12010-008-8464-0

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  • DOI: https://doi.org/10.1007/s12010-008-8464-0

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