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Constrained Total Hip Megaprosthesis for Primary Periacetabular Tumors

  • Symposium: Papers Presented at the 2011 ISOLS Meeting in Beijing, China
  • Published:
Clinical Orthopaedics and Related Research®

Abstract

Background

Limb-salvage reconstruction for periacetabular malignant tumors is one of the most challenging problems in orthopaedic oncology. Reconstructive options include resection arthroplasty, endoprosthesis, allograft, recycled autobone graft, arthrodesis, and pseudarthrosis. However, no standard procedure exists because of rarity and clinical variability of the disease. We previously developed a megaprosthetic system with a constrained total hip mechanism (C-THA).

Questions/purposes

We evaluated (1) survival of patients and C-THA; (2) postoperative function; and (3) complications.

Methods

We retrospectively reviewed 25 patients with primary periacetabular tumors treated using C-THA between 1985 and 2009. There were 18 male and seven female patients with a median age of 44 years (range, 16–72 years). They included 11 chondrosarcomas, eight osteosarcomas, two giant cell tumors of bone (one locally aggressive benign, one malignant), and others in four. Surgical margin was wide in 18 patients, marginal in five, and intralesional in two. The minimum postoperative followup for survivors was 32 months (median, 163 months; range, 32–285 months).

Results

The 10-year overall survival rate of all patients was 47%. C-THA implants survived in 19 of 25 patients at last followup. Twenty-one patients acquired ambulatory activity. There were seven local recurrences, resulting in hemipelvectomy in one patient. Postoperative complications included deep infection in eight of the 25 patients, dislocation in four, and aseptic loosening in two, necessitating five revision surgeries and three implant removals.

Conclusions

Our observations suggest C-THA using an acetabular reconstruction cup is a useful reconstructive option after resection of periacetabular malignant tumors despite frequent postoperative complications.

Level of Evidence

Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

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Acknowledgments

We primarily thank Prof Atsumasa Uchida for his major contribution to the development of this C-THA system. We also thank Dr Norifumi Naka for his assistance with data collection and Dr Nobuyuki Hashimoto, Dr Kenichiro Hamada, Dr Susumu Joyama, Dr Ikuo Kudawara, and Dr Akira Myoui for their dedication to the treatment of the patients and their assistance with data analysis.

Author information

Authors and Affiliations

  1. Osaka University Orthopaedic Oncology Group, Osaka, Japan

    Takafumi Ueda MD, PhD, Shigeki Kakunaga MD, PhD, Satoshi Takenaka MD, PhD, Nobuhito Araki MD, PhD & Hideki Yoshikawa MD, PhD

  2. Department of Orthopaedic Surgery, Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka, 540-0006, Japan

    Takafumi Ueda MD, PhD & Shigeki Kakunaga MD, PhD

  3. Department of Orthopaedics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

    Satoshi Takenaka MD, PhD & Hideki Yoshikawa MD, PhD

  4. Department of Orthopaedic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan

    Nobuhito Araki MD, PhD

Authors
  1. Takafumi Ueda MD, PhD
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  2. Shigeki Kakunaga MD, PhD
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  3. Satoshi Takenaka MD, PhD
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Corresponding author

Correspondence to Takafumi Ueda MD, PhD.

Additional information

No funding was received in support of this study. One or more of the authors (TU, NA) have been involved in the development of this reconstruction cup implant system possibly with some conflict of interests or biases in connection with this article.

All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research editors and board members are on file with the publication and can be viewed on request.

Clinical Orthopaedics and Related Research neither advocates nor endorses the use of any treatment, drug, or device. Readers are encouraged to always seek additional information, including FDA-approval status, of any drug or device prior to clinical use.

Each author certifies that his or her institution approved the human protocol for this investigation, that all investigations were conducted in conformity with ethical principles of research, and approval for informed consent for participation in the retrospective study was obtained.

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Ueda, T., Kakunaga, S., Takenaka, S. et al. Constrained Total Hip Megaprosthesis for Primary Periacetabular Tumors. Clin Orthop Relat Res 471, 741–749 (2013). https://doi.org/10.1007/s11999-012-2625-8

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  • DOI: https://doi.org/10.1007/s11999-012-2625-8

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