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Cardiotoxicities of Modern Treatments in Breast Cancer

  • Cardio-oncology (M Fradley, Section Editor)
  • Published:
Current Treatment Options in Cardiovascular Medicine Aims and scope Submit manuscript

Abstract

Purpose of review

This paper will focus on novel breast cancer therapies used in clinical practice today, as well as review our understanding of standard therapies and their potential impact on cardiovascular health.

Recent findings

Established and novel treatments such as anthracyclines, HER2-targeted agents, and immunotherapy have contributed to improvements in breast cancer outcomes; however, these treatments may be associated with an increased risk of cardiovascular injury. The number of available breast cancer treatments continues to expand, as does the need for health care providers to understand the potential impact of these treatments on cardiovascular health.

Summary

Collaborative approaches in the development of risk stratification, prevention, and surveillance strategies for patients exposed to established and novel breast cancer treatments will facilitate improvements in patient outcomes without compromising their cardiovascular health.

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Acknowledgments

The authors would like to thank Erin Campbell, MS, for her editorial contributions to this manuscript.

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Authors and Affiliations

  1. Duke Cancer Institute, Duke University, DUMC Box 3446, Durham, NC, 27710, USA

    Susan Dent MD, FRCPC

  2. Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA

    Chiara Melloni MD

  3. Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

    Josee Ivars MS

  4. Duke Cancer Institute, Duke University, DUMC Box 3893 Building, Durham, NC, 27710, USA

    Sarah Sammons MD

  5. Duke Cancer Institute, Duke University, DUMC Box 3204, Durham, NC, 27710, USA

    Gretchen Kimmick MD

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Correspondence to Susan Dent MD, FRCPC.

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Conflict of Interest

Susan Dent has received honorarium from Novartis, Pfizer and Hoffman La-Roche. Chiara Melloni receives support for research from the NICHD (HHSN27500027, HHSN27500043). All industry disclosures are available at: www.dcri.org/about-us/conflict-of-interest/. Josee Ivars declares no potential conflicts of interest. Sarah Sammons reports a grant from Astra Zeneca. Gretchen Kimmick is on the scientific advisory boards of Boehringer Ingelheim, Eisai, Genomic Health and Agendia. Dr. Kimmick is a consultant for AstraZeneca, Novartis, and Pfizer and has received research funding from Bionovo, PUMA, and Roche.

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Dent, S., Melloni, C., Ivars, J. et al. Cardiotoxicities of Modern Treatments in Breast Cancer. Curr Treat Options Cardio Med 21, 34 (2019). https://doi.org/10.1007/s11936-019-0738-z

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