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Cardiovascular Complications of Multiple Myeloma Treatment: Evaluation, Management, and Prevention

  • Cardio-oncology (M Fradley, Section Editor)
  • Published:
Current Treatment Options in Cardiovascular Medicine Aims and scope Submit manuscript

Abstract

Purpose of review

Multiple myeloma treatment regimens consist of proteasome inhibitors (bortezomib, carfilzomib, and ixazomib), immunomodulatory drugs (thalidomide, lenalidomide, and pomalidomide), and steroids. In this paper, we will review the pathophysiology and associated cardiotoxicities of the different multiple myeloma therapeutic modalities and present methods to mitigate the development of cardiovascular complications.

Recent findings

Although proteasome inhibitors and immunomodulatory drugs have led to significant improvements in oncologic outcomes, there is increasing evidence of serious cardiovascular side effects which may be exacerbated in the setting of underlying cardiovascular risk factors or disease. Cardiotoxicities include cardiomyopathy and heart failure, accelerated hypertension, arrhythmias, and both arterial and venous thromboembolism.

Summary

Given the frequency of cardiovascular risk factors in multiple myeloma patients as well as the cardiotoxicities associated with the different treatment regimens, it is essential to closely monitor these patients. Collaboration between cardiologists and oncologists is necessary to ensure patients receive optimal cancer treatment while minimizing cardiovascular risk.

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Authors and Affiliations

  1. Department of Internal Medicine, University of South Florida, 2 Tampa General Circle, Tampa, FL, 33606, USA

    Dae Hyun Lee MD

  2. Department of Cardiovascular Sciences, University of South Florida, 2 Tampa General Circle, Tampa, FL, 33606, USA

    Michael G. Fradley MD

  3. Cardio-Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

    Michael G. Fradley MD

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  1. Dae Hyun Lee MD
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  2. Michael G. Fradley MD
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Correspondence to Michael G. Fradley MD.

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Dae Hyun Lee declares no potential conflicts of interest.

Michael G. Fradley is a section editor for Current Treatment Options in Cardiovascular Medicine.

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This article is part of the Topical Collection on Cardio-oncology

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Lee, D.H., Fradley, M.G. Cardiovascular Complications of Multiple Myeloma Treatment: Evaluation, Management, and Prevention. Curr Treat Options Cardio Med 20, 19 (2018). https://doi.org/10.1007/s11936-018-0618-y

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