Scoping Review and Meta-analysis of Hyperbaric Oxygen Therapy for Radiation-Induced Hemorrhagic Cystitis

  • James Cardinal
  • Austen Slade
  • Mary McFarland
  • Sorena Keihani
  • James N. Hotaling
  • Jeremy B. Myers
Surgery (J Simhan, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Surgery


Purpose of review

To critically review and summarize existing literature assessing the effectiveness of hyperbaric oxygen therapy (HBOT) for the treatment of radiation-induced urologic injury.

Recent findings

Though 5 of the included 13 studies were published in the last 2–3 years, the only randomized controlled study was performed in 2012. Recent studies have confirmed the safety and efficacy of HBOT as well as identified risk factors for success vs. failure of HBOT for hemorrhagic radiation cystitis (HRC).


Of the 602 patients that received HBOT for HRC, 84% had a partial or complete resolution. In the 7 studies that utilized RTOG/EORTC, 75% of patients saw an improvement in hematuria of at least one grade (out of possible 5 total). Of the 499 patients with documented follow-up, 14% experienced recurrence, with a median time to recurrence of 10 months (6 to 16.5 months).


Hyperbaric oxygen therapy HBOT Hemorrhagic radiation cystitis Radiation cystitis Urologic radiation injury Radiation-induced urethral stricture 


Compliance with Ethical Standards

Conflict of Interest

James Cardinal, Austen Slade, Mary McFarland, Sorena Keihani, and James N. Hotaling each declare no potential conflicts of interest.

Jeremy B. Myers reports grants from PCORI Foundation, Department of Defense, and Boston Scientific.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • James Cardinal
    • 1
  • Austen Slade
    • 1
  • Mary McFarland
    • 2
  • Sorena Keihani
    • 1
  • James N. Hotaling
    • 1
  • Jeremy B. Myers
    • 1
  1. 1.Division of Urology, Department of SurgeryUniversity of UtahSalt Lake CityUSA
  2. 2.Spencer S. Eccles Health Sciences LibraryUniversity of UtahSalt Lake CityUSA

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