Abstract
Insomnia among children and adolescents is ubiquitous and takes a great toll on youth and their families, impacting academic achievement, mood, social functioning, and a variety of developmental outcomes. Unfortunately, however, pediatric insomnia most often remains unidentified and untreated. When treatment is provided, it is most often in the form of medications, which are not FDA approved for that indication in children and adolescents. A comprehensive literature review was employed to establish the recommendations in this report. This article provides a review of sleep physiology and both current and recommended approaches to assessing and treating pediatric insomnia. Comprehensive assessment, accurate diagnosis, and evidence-based treatment of insomnia is imperative to the healthy development of children and adolescents. While clinicians often prescribe a variety of medications to treat pediatric insomnia, there is insufficient data to demonstrate efficacy and endorse their routine use. At this time, behavioral techniques, such as cognitive behavior therapy for insomnia and sleep hygiene education, should remain the first line of treatment. As a second-line consideration, melatonin, a dietary supplement, may be effective. Pediatric insomnia has an enormous impact on children, adolescents, and their families that requires adequate attention from clinicians and parents alike.
Similar content being viewed by others
References
Papers of particular interest, published recently, have been highlighted as: • Of importance
Owens J. Classification and epidemiology of childhood sleep disorders. Prim Care. 2008;35:533–46.
Archbold KH, Pituch KJ, Panabi P, Chervin RD. Symptoms of sleep disturbances among children at two general pediatric clinics. J Pediatr. 2002;140:97–102.
Amschler DH, McKenzie JF. Elementary students’ sleep habits and teacher observations of sleep-related problems. J Sch Health. 2005;75:50–6.
Meltzer LJ, Johnson C, Crosette J, Ramos M, Mindell JA. Prevalence of diagnosed sleep disorders in pediatric primary care practices. Pediatrics. 2010;125:1410–7.
Sadeh A. Cognitive-behavioral treatment for childhood sleep disorders. Clin Psychol Rev. 2005;25:612–28.
Rosen RC, Zozula R, Jahn EG, Carson JL. Low rates of recognition of sleep disorders in primary care: comparison of a community-based versus clinical academic setting. Sleep Med. 2001;2:47–55. doi:10.1016/s1389-9457(00)00043-5.
National Sleep Foundation. What is insomnia? In: Insomnia. 2014. Retrieved from: http://sleepfoundation.org/insomnia/content/what-is-insomnia. Accessed 9 March 2016.
Honaker SM, Meltzer LJ. Sleep in pediatric primary care: a review of the literature. Sleep Med Rev. 2015;1–9. doi: 10.1016/j.smrv.2015.01.004. An important review of literature highlighting the high prevalence rates of insomnia among children and adolescents.
Owens JA, Rosen CL, Mindell JA, Kirchner HL. Use of pharmacotherapy for insomnia in child psychiatry practice: a national survey. Sleep Med. 2010;11:692–700.
Huedo-Medina TB, Kirsch I, Middlemass J, Klonizakis M, Siriwardena AN. Effectiveness of non-benzodiazepine hypnotics in treatment of adult insomnia: meta-analysis of data submitted to the Food and Drug Administration. BMJ. 2012;345:1–13.
Owens JA. The practice of pediatric sleep medicine: results of a community survey. Pediatrics. 2001;108:e51.
Owens JA, Dalzell V. Use of the “BEARS” sleep screening tool in pediatric residents’ continuity clinic: a pilot study. Sleep Med. 2005;6:63–9.
Byars KC, Yolton K, Rausch J, Lanphear B, Beebe DW. Prevalence, patterns, and persistence of sleep problems in the first 3 years of life. Pediatrics. 2012;129:276–84. doi:10.1542/peds.2011-0372.
Luginbuehl M, Kohler WC. Screening and evaluation of sleep disorders in children and adolescents. Child Adolesc Psychiatr Clin N Am. 2009;18:825–38. doi:10.1016/j.chc.2009.04.012.
Tikotzky L, Sadeh A. The role of cognitive-behavioral therapy in behavioral child insomnia. Sleep Med. 2010;11:686–91.
Taylor DJ, Roane BM. Treatment of insomnia in adults and children: a practice-friendly review of research. J Clin Psychol. 2010;66:1137–47. doi:10.1002/jclp.20733.
National Sleep Foundation. What is sleep hygiene? Sleep Hygiene. 2015. Retrieved from: http://sleepfoundation.org/ask-the-expert/sleep-hygiene. Accessed 9 March 2016.
Borbély AA. A two process model of sleep regulation. Hum Neurobiol. 1982;1:195–204.
Shatkin JP, Pando M. Diagnosis and treatment of common sleep disorders in adolescence. Adolesc Psychiatr. 2015;4:1–13. A vast review of the literature related to sleep disorders in adolescence and the common approaches to treating them.
Roehrs T, Roth T. Sleep, sleepiness, and alcohol use. Natl Inst Alcohol Abuse Alcoholism. 2001;25(2):101–9.
Krystal AD. Psychiatric disorders and sleep. Neurol Clin. 2012;30:1389–413. A review of the literature showing the negative effects of alcohol consumption on sleep.
Landolt HP, Roth C, Dijk DJ, Borbely AA. Late-afternoon ethanol intake affects nocturnal sleep and the sleep EEG in middle-aged men. J Clin Psychopharmacol. 1996;16:428–36.
Roehrs T, Roth T. Caffeine: sleep and daytime sleepiness. Sleep Med Rev. 2008;12:153–62.
Fisone G, Borgkvist A, Usiello A. Caffeine as a psychomotor stimulant: mechanism of action. Cell Mol Life Sci (CMLS). 2004;61:857–72.
Fuller PM, Gooley JJ, Saper CB. Neurobiology of the sleep-wake cycle: sleep architecture, circadian rhythm, and regulatory feedback. J Biol Rhythms. 2006;6:482–93.
Watson CJ, Baghdoyan HA, Lydic R. Neuropharmacology of sleep and wakefulness. Sleep Med Clin. 2010;5:513–28.
Harrison N, Mendelson WB, de Wit H. Barbiturates. Psychopharmacol—the fourth generation of progress. 2000. Retrieved from: http://www.acnp.org/g4/GN401000173/CH169.html. Accessed 9 March 2016.
Bianchi MT, Botzolakis EJ, Lagrange AH, Macdonald RL. Benzodiazepine modulation of GABAA receptor opening frequency depends on activation context: a patch clamp and simulation study. Epilepsy Res. 2009;85:212–20.
Beck Institute for Cognitive Behavior Therapy (n.d.) Cognitive behavior therapy. Retrieved from: https://www.beckinstitute.org/.Accessed 9 March 2016.
Ferber R. Childhood sleep disorders. Neurol Clin. 1996;3:493–511.
Knab B, Engel RR. Perception of waking and sleeping: possible implications for the evaluation of insomnia. Sleep. 1988;11:265–72.
Czeisler CA, Shanahan TL, Klerman EB, Martens H, Brotman DJ, Emens JS, et al. Suppression of melatonin secretion in some blind patients by exposure to bright light. N Engl J Med. 1995;1:6–11. doi:10.1056/nejm199501053320102.
Siebern AT, Manber RM. New developments in cognitive behavioral therapy as the first-line treatment of insomnia. Psychol Res Behav Manag. 2011;4:21–8.
Paine S, Gradisar M. A randomised controlled trial of cognitive-behaviour therapy for behavioural insomnia of childhood in school-aged children. Behav Res Ther. 2011; (6–7):379–88. doi:10.1016/j.brat.2011.03.008.
Ferguson SA, Rajaratnam SM, Dawson D. Melatonin agonists and insomnia. Expert Rev Neurother. 2010;10:305–18. doi:10.1586/ern.10.1.
van Geijlswijk IM, Korzilius HPLM, Smits MG. The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis. Sleep. 2010;33:1605–14.
Regestein QR, Monk TH. Delayed sleep phase syndrome: a review of its clinical aspects. Am J Psychiatry. 1995;152:602–8.
van der Heijden KB, Smits MG, van Someren EJ, Gunning WB. Prediction of melatonin efficacy by pretreatment dim light melatonin onset in children with idiopathic chronic sleep onset insomnia. J Sleep Res. 2005;14:187–94.
Prince JB, Wilens TE, Biederman J, Spencer TJ, Wozniak JR. Clonidine for sleep disturbances associated with attention-deficit hyperactivity disorder: a systematic chart review of 62 cases. J Am Acad Child Adolesc Psychiatry. 1996;35:599–605. doi:10.1097/00004583-199605000-00014.
Wilens TE, Biederman J, Spencer TJ, Prince J. Pharmacotherapy of adult attention deficit/hyperactivity disorder. J Clin Psychopharmacol. 1995;15:270–9. doi:10.1097/00004714-199508000-00006.
Brielmaier BD. Eszopiclone (Lunesta): a new nonbenzodiazepine hypnotic agent. Proc (Baylor Univ Med Cent). 2006;19:54–9.
Lahmeyer H, Wilcox H, Kann A, Leppik I. Subjective efficacy of zolpidem in outpatients with chronic insomnia: a double-blind comparison with placebo. Clin Drug Investig. 1997;13:134–44.
Russo R, Gururaj V, Allen J. The effectiveness of diphenhydramine HC1 in pediatric sleep disorders. J Clin Pharmacol. 1976;16:284–8.
Merenstein D, Diener-West M, Halbower AC, Krist A, Rubin HR. The trial of infant response to diphenhydramine: the TIRED study—a randomized controlled, patient-oriented trial. Arch Pediatr Adolesc Med. 2006;160:707–12.
Müller S, Klement S. A combination of valerian and lemon balm is effective in the treatment of restlessness and dyssomnia in children. Phytomedicine. 2006;13:383–7. doi:10.1016/j.phymed.2006.01.013.
Francis A, Dempster R. Effect of valerian, Valeriana edulis, on sleep difficulties in children with intellectual deficits: randomised trial. Phytomedicine. 2002;9:273–9. doi:10.1078/0944-7113-00110.
Perlis ML, Jungquist C, Smith MT, Posner D. Cognitive behavioral treatment of insomnia: a session-by-session guide. New York: Springer-Verlag; 2005.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
Emily Badin, Cynthia Haddad, and Jess Parker Shatkin declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Additional information
This article is part of the Topical Collection on Child and Adolescent Disorders
Rights and permissions
About this article
Cite this article
Badin, E., Haddad, C. & Shatkin, J.P. Insomnia: the Sleeping Giant of Pediatric Public Health. Curr Psychiatry Rep 18, 47 (2016). https://doi.org/10.1007/s11920-016-0687-0
Published:
DOI: https://doi.org/10.1007/s11920-016-0687-0