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Contextual Regulation of Skeletal Physiology by Notch Signaling

  • Skeletal Development (R Marcucio and J Feng, Section Editors)
  • Published:
Current Osteoporosis Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

This article reviews the past 2 years of research on Notch signaling as it relates to bone physiology, with the goal of reconciling seemingly discrepant findings and identifying fruitful areas of potential future research.

Recent Findings

Conditional animal models and high-throughput omics have contributed to a greater understanding of the context-dependent role of Notch signaling in bone. However, significant gaps remain in our understanding of how spatiotemporal context and epigenetic state dictate downstream Notch phenotypes.

Summary

Biphasic activation of Notch signaling orchestrates progression of mesenchymal progenitor cells through the osteoblast lineage, but there is a limited understanding of ligand- and receptor-specific functions. Paracrine Notch signaling through non-osteoblastic cell types contributes additional layers of complexity, and we anticipate impactful future work related to the integration of these cell types and signaling mechanisms.

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Funding

Daniel Youngstrom reports grants from National Institutes of Health (F32DE026346) during the conduct of the study.

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  1. Department of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Pl, Ann Arbor, MI, 48872, USA

    Daniel W. Youngstrom & Kurt D. Hankenson

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  1. Daniel W. Youngstrom
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Correspondence to Daniel W. Youngstrom.

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Kurt Hankenson reports he was co-founder of Skelegen LLC, and has received a research grant from Orthofix. Both are outside the submitted work.

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Youngstrom, D.W., Hankenson, K.D. Contextual Regulation of Skeletal Physiology by Notch Signaling. Curr Osteoporos Rep 17, 217–225 (2019). https://doi.org/10.1007/s11914-019-00516-y

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