Recent Advances in Understanding Bisphosphonate Effects on Bone Mechanical Properties
Purpose of the Review
Bisphosphonates have well-established effects on suppressing bone resorption and slowing bone loss, yet the effects on bone mechanical properties are less clear. We review recent data from pre-clinical and clinical experiments that assessed mechanical properties of bisphosphonate-treated specimens.
Pre-clinical work has utilized new techniques to show reduced fatigue life and transfer of stress from the mineral to collagen. Several notable studies have examined mechanical properties of tissue from patients treated with bisphosphonates with mixed results. Pre-clinical data suggest effects on mechanics may be independent of remodeling suppression.
The direct effect of bisphosphonates on bone mechanics remains unclear but recent work has set a solid foundation for the coming years.
KeywordsAtypical fracture Zoledronate Remodeling suppression Anti-remodeling Biomechanics
Compliance with Ethical Standards
Conflict of Interest
Matthew Allen declares no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: •• Of major importance
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