Current Osteoporosis Reports

, Volume 16, Issue 2, pp 169–181 | Cite as

Progress of Regenerative Therapy in Orthopedics

  • Pearlin
  • Sunita Nayak
  • Geetha Manivasagam
  • Dwaipayan Sen
Regenerative Biology and Medicine in Osteoporosis (T Webster, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Regenerative Biology and Medicine in Osteoporosis


Purpose of Review

To conduct a thorough appraisal of recent and inventive advances in the field of bone tissue engineering using biomaterials, cell-based research, along with the incorporation of biomimetic properties using surface modification of scaffolds.

Recent Findings

This paper will provide an overview on different biomaterials and emerging techniques involved in the fabrication of scaffolds, brief description of signaling pathways involved in osteogenesis, and the effect of surface modification on the fate of progenitor cells.


The current strategies used for regenerative medicine like cell therapy, gene transfer, and tissue engineering have opened numerous therapeutic avenues for the treatment of various disabling orthopedic disorders. Precise strategy utilized for the reconstruction, restoration, or repair of the bone-related tissues exploits cells, biomaterials, morphogenetic signals, and appropriate mechanical environment to provide the basic constituents required for creating new tissue. Combining all the above strategies in clinical trials would pave the way for successful “bench to bedside” transformation in bone healing.


Bone tissue engineering Stem cells Osteogenesis Scaffold Biomaterial 



The authors thank A. Revathi for carefully proof-reading the manuscript.

Compliance with Ethical Standards

Conflict of Interest

Pearlin, Sunita Nayak, Geetha Manivasgam and Dwaipayan Sen declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance, ••Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Centre for Biomaterials, Cellular and Molecular Theranostics (CBCMT), VITVelloreIndia

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