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T Regulatory Cells in Bone Remodelling

  • Osteoimmunology (M Nakamura and M Humphrey, Section Editors)
  • Published:
Current Osteoporosis Reports Aims and scope Submit manuscript

Abstract

Purpose of the Review

In this review, we present the role of regulatory T (Treg) cells in bone remodelling and bone-related disease such as osteoporosis or inflammatory bone loss. We also discuss the cellular and molecular mechanism how Treg cells regulate osteoclastogenesis.

Recent Findings

Treg cells could regulate osteoclastogenesis by secreting TGF-β and IL-10 as well as IL-4 cytokines. Moreover, Treg cells can additionally regulate osteoclast differentiation, in a cell-to-cell contact via the cytotoxic T lymphocyte antigen (CTLA-4). The latter induces the apoptosis of osteoclasts dependent on CD80/86 in vitro and in vivo.

Summary

Treg cells mediate immunosuppressive function that controls undesired immune reactions, such as autoimmunity. Recently, Treg cells have been shown to influence non-immunological processes, such as bone homeostasis. Accumulated evidences have demonstrated that Treg cells can suppress osteoclast differentiation in vitro and in vivo.

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Acknowledgments

This study was supported by the Deutsche Forschungsgemeinschaft (CRC1181-A01, SPP1468, IMMUNOBONE; BO3811/1-1, Emmy Noether to A.B, and SPP1937 to M.M.Z.).

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Authors and Affiliations

  1. Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany

    Aline Bozec & Mario M. Zaiss

Authors
  1. Aline Bozec
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  2. Mario M. Zaiss
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Correspondence to Aline Bozec.

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Conflict of Interest

Aline Bozec and Mario Zaiss declare no conflict of interest.

Human and Animal Rights and Informed Consent

All report studies with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards.

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This article is part of the Topical Collection on Osteoimmunology

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Bozec, A., Zaiss, M.M. T Regulatory Cells in Bone Remodelling. Curr Osteoporos Rep 15, 121–125 (2017). https://doi.org/10.1007/s11914-017-0356-1

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