Skip to main content
SpringerLink
Log in

Bone Quality in Paget’s Disease of Bone

  • Epidemiology and Pathophysiology (B Dawson-Hughes and J Cauley, Section Editors)
  • Published:
Current Osteoporosis Reports Aims and scope Submit manuscript

Abstract

Paget’s disease of bone is produced by a localized increase in osteoclastic and osteoblastic activity which can progress slowly to involve an entire bone if untreated. A common feature is enlarged bones which are deformed, particularly in weight-bearing regions of the skeleton such as the lower extremity. Pathologic fractures may be a consequence, and nonunion of femoral fractures is not uncommon. Analyses of bone biopsies from patients with Paget’s disease indicate that there is a lower, heterogeneous degree of bone mineralization and a younger tissue age than that found in control bone. Pagetic bone also has less resistance to plastic deformation and a straighter crack path than control bone.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Singer FR. Paget’s disease of bone. In: Jameson JL, DeGroot LJ, editors. In: Endocrinology, adult and pediatric. Seventhth ed. Saunders: Elsevier; 2016. p. 1244–54. This is an up-to-date general review of Paget’s disease.

    Chapter  Google Scholar 

  2. Corral-Gudino L, Borao-Cengotita-Bengoa M, Del Pino-Montes J, Ralston S. Epidemiology of Paget’s disease of bone: a systematic review and meta-analysis of secular changes. Bone. 2013;55:347–52.

    Article  PubMed  Google Scholar 

  3. Singer FR. Paget’s disease of bone-genetic and environmental factors. Nat Rev Endocrinol. 2015;11(11):662–71.

    Article  CAS  PubMed  Google Scholar 

  4. Barry HC. Fractures. In: Paget’s disease of bone. Edinburgh: E & S Livingston Ltd; 1969. p. 105–35. This is the most extensive review of fractures in Paget’s disease.

    Google Scholar 

  5. Pande KC, Bernard J, McCloskey EV, de Takats D, Kanis JA. Ultrasound velocity and dual-energy X-ray absorptiometry in normal and pagetic bone. Bone. 2000;26(5):525–8.

    Article  CAS  PubMed  Google Scholar 

  6. McCloskey EV, Murray SA, Miller C, Charlesworth D, Tindale W, O’Doherty DP, et al. Broadband ultrasound attenuation in the os calcis: relationship to bone mineral at other skeletal sites. Clin Sci. 1990;78(2):227–33.

    Article  CAS  PubMed  Google Scholar 

  7. Zimmermann EA, Köhne T, Bale HA, Panganiban B, Gludovatz B, Zustin J, et al. Modifications to nano- and microstructural quality and the effects on mechanical integrity in Paget’s disease of bone. J Bone Miner Res. 2015;30(2):264–73. This is the most important analysis of bone quality in Paget’s disease.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Endocrine/Bone Disease Program, John Wayne Cancer Institute, Providence Saint John’s Health Center, Santa Monica, CA, USA

    Frederick R. Singer

  2. Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA

    Frederick R. Singer

Authors
  1. Frederick R. Singer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Frederick R. Singer.

Ethics declarations

Conflict of Interest

Frederick R. Singer declares no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Epidemiology and Pathophysiology

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Singer, F.R. Bone Quality in Paget’s Disease of Bone. Curr Osteoporos Rep 14, 39–42 (2016). https://doi.org/10.1007/s11914-016-0303-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11914-016-0303-6

Keywords

Search

Navigation