The Evolving Role of Radiation Therapy in Patients with Metastatic Soft Tissue Sarcoma

Abstract

Purpose of Review

The management of metastatic disease is evolving. As systemic therapies continue to improve, there is increasing recognition that local therapy to distant sites of disease impacts outcomes among many histologies, including sarcoma. Various local therapy strategies exist, but radiation therapy (RT) is particularly critical as it provides a non-invasive, yet locally ablative strategy for metastatic management.

Recent Findings

Various delivery techniques including stereotactic body radiation therapy (SBRT) or hypofractionated RT can escalate the biologic dose while avoiding normal tissues in order to reduce tumor burden, provide durable local control, palliate symptoms, potentially prevent further seeding of metastatic lesions, and potentially prolong survival.

Summary

This review summarizes the current state of the literature on the important role of RT for the treatment of metastatic sarcoma organized by the site of metastatic disease. Particularly for patients presenting with oligometastatic or oligoprogressive disease, consolidative RT is an important local therapy strategy to be considered in a multidisciplinary setting.

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Fig. 1

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Correspondence to Andrew J. Bishop.

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This article is part of the Topical Collection on Sarcomas

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Farooqi, A., Mitra, D., Guadagnolo, B.A. et al. The Evolving Role of Radiation Therapy in Patients with Metastatic Soft Tissue Sarcoma. Curr Oncol Rep 22, 79 (2020). https://doi.org/10.1007/s11912-020-00936-5

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Keywords

  • Sarcoma
  • Metastatic
  • Radiation
  • Stereotactic radiation
  • Stereotactic body radiation therapy
  • Palliative radiation