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Prehabilitative Exercise for the Enhancement of Physical, Psychosocial, and Biological Outcomes Among Patients Diagnosed with Cancer

  • Cardio-oncology (EH Yang, Section Editor)
  • Published:
Current Oncology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

This review summarizes the effects of prehabilitative exercise interventions on the physical, psychosocial, and biological outcomes among patients with cancer. Current gaps and future directions in prehabilitative exercise research will be addressed.

Recent Findings

Prehabilitative exercise mitigates the detrimental impact of cancer surgery on physical fitness, noted by increases in maximal oxygen consumption and 6-min walk distance. Beneficial effects on psychosocial and biological outcomes remain inconclusive. Aerobic exercise interventions were often prescribed and included low-, moderate-, or high-intensity exercise. Resistance exercise interventions were often performed in conjunction with aerobic exercise.

Summary

Prehabilitative exercise elicits robust improvements in physical fitness; however, effect on psychosocial and biological outcomes remains inconclusive. Exercise prescription parameters varied greatly by frequency, intensity, time, and type across multiple cancer diagnoses. Future investigations are needed to systematically dose exercise for a wider variety of outcome measures, with an overall goal to set forth pre-operative exercise guidelines.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Dronkers JJ, Lamberts H, Reutelingsperger IMMD, Naber RH, Dronkers-Landman CM, Veldman A, et al. Preoperative therapeutic programme for elderly patients scheduled for elective abdominal oncological surgery: a randomized controlled pilot study. Clin Rehabil. 2010;24(7):614–22.

    CAS  PubMed  Google Scholar 

  2. Carli F, Charlebois P, Stein B, Feldman L, Zavorsky G, Kim DJ, et al. Randomized clinical trial of prehabilitation in colorectal surgery. Br J Surg. 2010;97(8):1187–97.

    CAS  PubMed  Google Scholar 

  3. Li C, Carli F, Lee L, Charlebois P, Stein B, Liberman AS, et al. Impact of a trimodal prehabilitation program on functional recovery after colorectal cancer surgery: a pilot study. Surg Endosc. 2013;27(4):1072–82.

    PubMed  Google Scholar 

  4. • Gillis C, et al. Prehabilitation versus rehabilitation a randomized control trial in patients undergoing colorectal resection for cancer. Anesthesiology. 2014;121(5):937–47. This study compared an exercise prehabilitation + rehabilitation group to a rehabilitation only group and found improved postoperative outcomes with the addition of prehabilitation.

    PubMed  Google Scholar 

  5. Pouwels S, Hageman D, Gommans LNM, Willigendael EM, Nienhuijs SW, Scheltinga MR, et al. Preoperative exercise therapy in surgical care: a scoping review. J Clin Anesth. 2016;33:476–90.

    PubMed  Google Scholar 

  6. • Treanor C, Kyaw T, Donnelly M. An international review and meta-analysis of prehabilitation compared to usual care for cancer patients. J Cancer Surviv. 2018;12(1):64–73. This review found that earlier prehabilitation intervention may lead to better cancer survivorship outcomes, for example, faster continence recovery (prostate cancer) and fewer days in the hospital (lung cancer).

    CAS  PubMed  Google Scholar 

  7. Bolshinsky V, Li MHG, Ismail H, Burbury K, Riedel B, Heriot A. Multimodal prehabilitation programs as a bundle of care in gastrointestinal cancer surgery: a systematic review. Dis Colon Rectum. 2018;61(1):124–38.

    PubMed  Google Scholar 

  8. O'Neill L, et al. Physical decline and its implications in the management of oesophageal and gastric cancer: a systematic review. J Cancer Surviv. 2018;12(4):601–18.

    PubMed  Google Scholar 

  9. Chen C, Koh GCH, Naidoo N, Cheong A, Fong NP, Tan YV, et al. Trends in length of stay, functional outcomes, and discharge destination stratified by disease type for inpatient rehabilitation in Singapore community hospitals from 1996 to 2005. Arch Phys Med Rehabil. 2013;94(7):1342–51 e4.

    PubMed  Google Scholar 

  10. Stefanelli F, Meoli I, Cobuccio R, Curcio C, Amore D, Casazza D, et al. High-intensity training and cardiopulmonary exercise testing in patients with chronic obstructive pulmonary disease and non-small-cell lung cancer undergoing lobectomy. Eur J Cardiothorac Surg. 2013;44(4):e260–5.

    PubMed  Google Scholar 

  11. Singh F, Newton RU, Baker MK, Spry NA, Taaffe DR, Thavaseelan J, et al. Feasibility of presurgical exercise in men with prostate cancer undergoing prostatectomy. Integr Cancer Ther. 2017;16(3):290–9.

    PubMed  Google Scholar 

  12. Ronning B, et al. Frailty indicators and functional status in older patients after colorectal cancer surgery. J Geriatr Oncol. 2014;5(1):26–32.

    PubMed  Google Scholar 

  13. Minnella EM, et al. Multimodal prehabilitation to enhance functional capacity following radical cystectomy: a randomized controlled trial. Eur Urol Focus. 2019.

  14. Epstein NE. A review article on the benefits of early mobilization following spinal surgery and other medical/surgical procedures. Surg Neurol Int. 2014;5(Suppl 3):S66–73.

    PubMed  PubMed Central  Google Scholar 

  15. Prado CM, Lieffers JR, McCargar LJ, Reiman T, Sawyer MB, Martin L, et al. Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet Oncol. 2008;9(7):629–35.

    PubMed  Google Scholar 

  16. Hamer J, McDonald R, Zhang L, Verma S, Leahey A, Ecclestone C, et al. Quality of life (QOL) and symptom burden (SB) in patients with breast cancer. Support Care Cancer. 2017;25(2):409–19.

    PubMed  Google Scholar 

  17. Wen Q, Shao Z, Zhang P, Zhu T, Li D, Wang S. Mental distress, quality of life and social support in recurrent ovarian cancer patients during active chemotherapy. Eur J Obstet Gynecol Reprod Biol. 2017;216:85–91.

    PubMed  Google Scholar 

  18. Christensen JF, Simonsen C, Banck-Petersen A, Thorsen-Streit S, Herrstedt A, Djurhuus SS, et al. Safety and feasibility of preoperative exercise training during neoadjuvant treatment before surgery for adenocarcinoma of the gastro-oesophageal junction. BJS Open. 2019;3(1):74–84.

    CAS  PubMed  Google Scholar 

  19. Pedersen L, Idorn M, Olofsson GH, Lauenborg B, Nookaew I, Hansen RH, et al. Voluntary running suppresses tumor growth through epinephrine- and IL-6-dependent NK cell mobilization and redistribution. Cell Metab. 2016;23(3):554–62.

    CAS  PubMed  Google Scholar 

  20. • Jones LW, et al. Effects of presurgical exercise training on cardiorespiratory fitness among patients undergoing thoracic surgery for malignant lung lesions. Cancer. 2007;110(3):590–8. This study directly showed that prehabilitative exercise has benefits on maximal oxygen consumption in lung cancer patients.

    PubMed  Google Scholar 

  21. Benzo R, Wigle D, Novotny P, Wetzstein M, Nichols F, Shen RK, et al. Preoperative pulmonary rehabilitation before lung cancer resection: results from two randomized studies. Lung Cancer. 2011;74(3):441–5.

    PubMed  Google Scholar 

  22. Jensen BT, Laustsen S, Jensen JB, Borre M, Petersen AK. Exercise-based pre-habilitation is feasible and effective in radical cystectomy pathways-secondary results from a randomized controlled trial. Support Care Cancer. 2016;24(8):3325–31.

    PubMed  Google Scholar 

  23. Karenovics W, Licker M, Ellenberger C, Christodoulou M, Diaper J, Bhatia C, et al. Short-term preoperative exercise therapy does not improve long-term outcome after lung cancer surgery: a randomized controlled study. Eur J Cardiothorac Surg. 2017;52(1):47–54.

    PubMed  Google Scholar 

  24. • Minnella EM, Bousquet-Dion G, Awasthi R, Scheede-Bergdahl C, Carli F. Multimodal prehabilitation improves functional capacity before and after colorectal surgery for cancer: a five-year research experience. Acta Oncol. 2017;56(2):295–300. This study pooled data from 3 trials utilizing trimodal prehabilitation (exercise, nutrition, and anxiety reduction) compared with a rehabilitation group and found improved walking capacity in the prehabilitation group throughout the perioperative period.

    PubMed  Google Scholar 

  25. Ngo-Huang A, Parker NH, Wang X, Petzel MQB, Fogelman D, Schadler KL, et al. Home-based exercise during preoperative therapy for pancreatic cancer. Langenbeck's Arch Surg. 2017;402(8):1175–85.

    Google Scholar 

  26. Banerjee S, Manley K, Shaw B, Lewis L, Cucato G, Mills R, et al. Vigorous intensity aerobic interval exercise in bladder cancer patients prior to radical cystectomy: a feasibility randomised controlled trial. Support Care Cancer. 2018;26(5):1515–23.

    PubMed  Google Scholar 

  27. Barassi G, et al. Preoperative rehabilitation in lung Cancer patients: yoga approach. Adv Exp Med Biol. 2018;1096:19–29.

    PubMed  Google Scholar 

  28. Bousquet-Dion G, Awasthi R, Loiselle SÈ, Minnella EM, Agnihotram RV, Bergdahl A, et al. Evaluation of supervised multimodal prehabilitation programme in cancer patients undergoing colorectal resection: a randomized control trial. Acta Oncol. 2018;57(6):849–59.

    PubMed  Google Scholar 

  29. Minnella EM, et al. Effect of exercise and nutrition prehabilitation on functional capacity in esophagogastric cancer surgery: a randomized clinical trial. JAMA Surg. 2018.

  30. Santa Mina D, Hilton WJ, Matthew AG, Awasthi R, Bousquet-Dion G, Alibhai SMH, et al. Prehabilitation for radical prostatectomy: a multicentre randomized controlled trial. Surg Oncol. 2018;27(2):289–98.

    PubMed  Google Scholar 

  31. Valkenet K, Trappenburg JCA, Ruurda JP, Guinan EM, Reynolds JV, Nafteux P, et al. Multicentre randomized clinical trial of inspiratory muscle training versus usual care before surgery for oesophageal cancer. Br J Surg. 2018;105(5):502–11.

    CAS  PubMed  Google Scholar 

  32. Alejo LB, et al. Exercise prehabilitation program for patients under neoadjuvant treatment for rectal cancer: a pilot study. J Cancer Res Ther. 2019;15(1):20–5.

    PubMed  Google Scholar 

  33. Boereboom CL, Blackwell JEM, Williams JP, Phillips BE, Lund JN. Short-term pre-operative high-intensity interval training does not improve fitness of colorectal cancer patients. Scand J Med Sci Sports. 2019;29:1383–91.

    PubMed  PubMed Central  Google Scholar 

  34. Gillis C, Fenton TR, Sajobi TT, Minnella EM, Awasthi R, Loiselle SÈ, et al. Trimodal prehabilitation for colorectal surgery attenuates post-surgical losses in lean body mass: a pooled analysis of randomized controlled trials. Clin Nutr. 2019;38(3):1053–60.

    PubMed  Google Scholar 

  35. Gravier FE, Bonnevie T, Boujibar F, Médrinal C, Prieur G, Combret Y, et al. Effect of prehabilitation on ventilatory efficiency in non-small cell lung cancer patients: a cohort study. J Thorac Cardiovasc Surg. 2019;157(6):2504–12 e1.

    PubMed  Google Scholar 

  36. Moug SJ, Mutrie N, Barry SJE, Mackay G, Steele RJC, Boachie C, et al. Prehabilitation is feasible in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy and may minimize physical deterioration: results from the REx trial. Color Dis. 2019;21(5):548–62.

    CAS  Google Scholar 

  37. Nakajima H, Yokoyama Y, Inoue T, Nagaya M, Mizuno Y, Kadono I, et al. Clinical benefit of preoperative exercise and nutritional therapy for patients undergoing hepato-pancreato-biliary surgeries for malignancy. Ann Surg Oncol. 2019;26(1):264–72.

    PubMed  Google Scholar 

  38. Sueppel C, Kreder K, See W. Improved continence outcomes with preoperative pelvic floor muscle strengthening exercises. Urol Nurs. 2001;21(3):201–10.

    CAS  PubMed  Google Scholar 

  39. Burgio KL, Goode PS, Urban DA, Umlauf MG, Locher JL, Bueschen A, et al. Preoperative biofeedback assisted behavioral training to decrease post-prostatectomy incontinence: a randomized, controlled trial. J Urol. 2006;175(1):196–201 discussion 201.

    PubMed  Google Scholar 

  40. Peddle CJ, Jones LW, Eves ND, Reiman T, Sellar CM, Winton T, et al. Effects of presurgical exercise training on quality of life in patients undergoing lung resection for suspected malignancy: a pilot study. Cancer Nurs. 2009;32(2):158–65.

    PubMed  Google Scholar 

  41. • Centemero A, et al. Preoperative pelvic floor muscle exercise for early continence after radical prostatectomy: a randomised controlled study. Eur Urol. 2010;57(6):1039–43. This study found that daily pelvic floor exercises for 30 days preoperatively improved continence in patients 1 and 3 months post-radical prostatectomy.

    PubMed  Google Scholar 

  42. • Jensen BT, et al. Multidisciplinary rehabilitation can impact on health-related quality of life outcome in radical cystectomy: secondary reported outcome of a randomized controlled trial. J Multidiscip Healthc. 2014;7:301–11. This study used a 2-week aerobic and resistance prehabilitation program combined with postoperative enhanced mobilization exercises compared with standard care and found improvement in quality of life following radical cystectomy in bladder cancer patients.

    PubMed  PubMed Central  Google Scholar 

  43. Sebio Garcia R, et al. Preoperative exercise training prevents functional decline after lung resection surgery: a randomized, single-blind controlled trial. Clin Rehabil. 2017;31(8):1057–67.

    PubMed  Google Scholar 

  44. Vainshelboim B, Lima RM, Edvardsen E, Myers J. Cardiorespiratory fitness, incidence and mortality of lung cancer in men: a prospective cohort study. J Sci Med Sport. 2019;22(4):403–7.

    PubMed  Google Scholar 

  45. • Verweij NM, et al. Physical performance measures for predicting outcome in cancer patients: a systematic review. Acta Oncol. 2016;55(12):1386–91. This study reported that declines in physical fitness and function observed in cancer patients result in profound increases in mortality rates.

    PubMed  Google Scholar 

  46. Schmid D, Leitzmann MF. Cardiorespiratory fitness as predictor of cancer mortality: a systematic review and meta-analysis. Ann Oncol. 2015;26(2):272–8.

    CAS  PubMed  Google Scholar 

  47. Laukkanen JA, Zaccardi F, Khan H, Kurl S, Jae SY, Rauramaa R. Long-term change in cardiorespiratory fitness and all-cause mortality: a population-based follow-up study. Mayo Clin Proc. 2016;91(9):1183–8.

    PubMed  Google Scholar 

  48. Ahlund K, et al. Preserved physical fitness is associated with lower 1-year mortality in frail elderly patients with a severe comorbidity burden. Clin Interv Aging. 2019;14:577–86.

    PubMed  PubMed Central  Google Scholar 

  49. Vainshelboim B, Müller J, Lima RM, Nead KT, Chester C, Chan K, et al. Cardiorespiratory fitness, physical activity and cancer mortality in men. Prev Med. 2017;100:89–94.

    PubMed  Google Scholar 

  50. Peel AB, et al. Cardiorespiratory fitness in breast cancer patients: a call for normative values. J Am Heart Assoc. 2014;3(1).

  51. Curtis NJ, West MA, Salib E, Ockrim J, Allison AS, Dalton R, et al. Time from colorectal cancer diagnosis to laparoscopic curative surgery-is there a safe window for prehabilitation? Int J Color Dis. 2018;33(7):979–83.

    CAS  Google Scholar 

  52. Shun SC. Cancer prehabilitation for patients starting from active treatment to surveillance. Asia Pac J Oncol Nurs. 2016;3(1):37–40.

    PubMed  PubMed Central  Google Scholar 

  53. • Licker M, et al. Short-term preoperative high-intensity interval training in patients awaiting lung cancer surgery: a randomized controlled trial. J Thorac Oncol. 2017;12(2):323–33. This study utilized a high intensity interval traning as a prehabilitave exercise and showed a significant improvement in maximal oxygen consumption in lung cancer patients.

    PubMed  Google Scholar 

  54. Repka CP, Peterson BM, Brown JM, Lalonde TL, Schneider CM, Hayward R. Cancer type does not affect exercise-mediated improvements in cardiorespiratory function and fatigue. Integr Cancer Ther. 2014;13(6):473–81.

    PubMed  Google Scholar 

  55. Lee CHA, Kong JC, Ismail H, Riedel B, Heriot A. Systematic review and meta-analysis of objective assessment of physical fitness in patients undergoing colorectal cancer surgery. Dis Colon Rectum. 2018;61(3):400–9.

    PubMed  Google Scholar 

  56. West MA, Astin R, Moyses HE, Cave J, White D, Levett DZH, et al. Exercise prehabilitation may lead to augmented tumor regression following neoadjuvant chemoradiotherapy in locally advanced rectal cancer. Acta Oncol. 2019;58(5):588–95.

    CAS  PubMed  Google Scholar 

  57. Chen BP, Awasthi R, Sweet SN, Minnella EM, Bergdahl A, Santa Mina D, et al. Four-week prehabilitation program is sufficient to modify exercise behaviors and improve preoperative functional walking capacity in patients with colorectal cancer. Support Care Cancer. 2017;25(1):33–40.

    PubMed  Google Scholar 

  58. Moyes LH, McCaffer C, Carter RC, Fullarton GM, Mackay CK, Forshaw MJ. Cardiopulmonary exercise testing as a predictor of complications in oesophagogastric cancer surgery. Ann R Coll Surg Engl. 2013;95(2):125–30.

    CAS  PubMed  PubMed Central  Google Scholar 

  59. Minnella EM, Ferri L, Carli F. Considerations in prehabilitation for esophagogastric cancer surgery reply. JAMA Surg. 2019;154(5):463–4.

    PubMed  Google Scholar 

  60. Wall BA, et al. Exercise improves V O2max and body composition in androgen deprivation therapy-treated prostate cancer patients. Med Sci Sports Exerc. 2017;49(8):1503–10.

    PubMed  Google Scholar 

  61. Novara G, Catto JWF, Wilson T, Annerstedt M, Chan K, Murphy DG, et al. Systematic review and cumulative analysis of perioperative outcomes and complications after robot-assisted radical cystectomy. Eur Urol. 2015;67(3):376–401.

    PubMed  Google Scholar 

  62. West MA, Loughney L, Lythgoe D, Barben CP, Sripadam R, Kemp GJ, et al. Effect of prehabilitation on objectively measured physical fitness after neoadjuvant treatment in preoperative rectal cancer patients: a blinded interventional pilot study. Br J Anaesth. 2015;114(2):244–51.

    CAS  PubMed  Google Scholar 

  63. Clauss D, Tjaden C, Hackert T, Schneider L, Ulrich CM, Wiskemann J, et al. Cardiorespiratory fitness and muscle strength in pancreatic cancer patients. Support Care Cancer. 2017;25(9):2797–807.

    PubMed  Google Scholar 

  64. Pamoukdjian F, Paillaud E, Zelek L, Laurent M, Lévy V, Landre T, et al. Measurement of gait speed in older adults to identify complications associated with frailty: a systematic review. J Geriatr Oncol. 2015;6(6):484–96.

    PubMed  Google Scholar 

  65. Handforth C, Clegg A, Young C, Simpkins S, Seymour MT, Selby PJ, et al. The prevalence and outcomes of frailty in older cancer patients: a systematic review. Ann Oncol. 2015;26(6):1091–101.

    CAS  PubMed  Google Scholar 

  66. Branicki FJ, Law SY, Fok M, Poon RT, Chu KM, Wong J. Quality of life in patients with cancer of the esophagus and gastric cardia: a case for palliative resection. Arch Surg. 1998;133(3):316–22.

    CAS  PubMed  Google Scholar 

  67. Marventano S, et al. Health related quality of life in colorectal cancer patients: state of the art. BMC Surg. 2013;13(Suppl 2):S15.

    PubMed  PubMed Central  Google Scholar 

  68. Courneya KS, Friedenreich CM. Physical exercise and quality of life following cancer diagnosis: a literature review. Ann Behav Med. 1999;21(2):171–9.

    CAS  PubMed  Google Scholar 

  69. Chen HM, Tsai CM, Wu YC, Lin KC, Lin CC. Randomised controlled trial on the effectiveness of home-based walking exercise on anxiety, depression and cancer-related symptoms in patients with lung cancer. Br J Cancer. 2015;112(3):438–45.

    PubMed  Google Scholar 

  70. Polanski J, Jankowska-Polanska B, Rosinczuk J, Chabowski M, Szymanska-Chabowska A. Quality of life of patients with lung cancer. Onco Targets Ther. 2016;9:1023–8.

    PubMed  PubMed Central  Google Scholar 

  71. Peng YN, Huang ML, Kao CH. Prevalence of depression and anxiety in colorectal cancer patients: a literature review. Int J Environ Res Public Health. 2019;16(3).

  72. Spector NM, Hicks FD, Pickleman J. Quality of life and symptoms after surgery for gastroesophageal cancer: a pilot study. Gastroenterol Nurs. 2002;25(3):120–5.

    PubMed  Google Scholar 

  73. Chen CY, Hsieh VC, Chang CH, Chen PR, Liang WM, Pan SC, et al. Impacts of treatments on the quality of life among esophageal squamous cell carcinoma patients. Dis Esophagus. 2017;30(10):1–8.

    CAS  PubMed  Google Scholar 

  74. Lane A, Metcalfe C, Young GJ, Peters TJ, Blazeby J, Avery KNL, et al. Patient-reported outcomes in the ProtecT randomized trial of clinically localized prostate cancer treatments: study design, and baseline urinary, bowel and sexual function and quality of life. BJU Int. 2016;118(6):869–79.

    PubMed  PubMed Central  Google Scholar 

  75. Ocampo-Trujillo A, Carbonell-González J, Martínez-Blanco A, Díaz-Hung A, Muñoz CA, Ramírez-Vélez R. Pre-operative training induces changes in the histomorphometry and muscle function of the pelvic floor in patients with indication of radical prostatectomy. Actas Urol Esp. 2014;38(6):378–84.

    CAS  PubMed  Google Scholar 

  76. Lauridsen SV, Tønnesen H, Jensen BT, Neuner B, Thind P, Thomsen T. Complications and health-related quality of life after robot-assisted versus open radical cystectomy: a systematic review and meta-analysis of four RCTs. Syst Rev. 2017;6(1):150.

    PubMed  PubMed Central  Google Scholar 

  77. Wall LM. Changes in hope and power in lung cancer patients who exercise. Nurs Sci Q. 2000;13(3):234–42.

    CAS  PubMed  Google Scholar 

  78. Jones LW, Eves ND, Peddle CJ, Courneya KS, Haykowsky M, Kumar V, et al. Effects of presurgical exercise training on systemic inflammatory markers among patients with malignant lung lesions. Appl Physiol Nutr Metab. 2009;34(2):197–202.

    CAS  PubMed  Google Scholar 

  79. Demark-Wahnefried W, Rais-Bahrami S, Desmond RA, Gordetsky JB, Hunter GR, Yang ES, et al. Presurgical weight loss affects tumour traits and circulating biomarkers in men with prostate cancer. Br J Cancer. 2017;117(9):1303–13.

    CAS  PubMed  PubMed Central  Google Scholar 

  80. • Ligibel JA, et al. Impact of a pre-operative exercise intervention on breast cancer proliferation and gene expression: results from the pre-operative health and body (PreHAB) study. Clin Cancer Res. 2019. This study found that exercise prehabilitation did not change cellular proliferation markers but significantly changed gene expression in breast cancer tumors.

  81. Jiang W, Zhu Z, Thompson HJ. Effects of physical activity and restricted energy intake on chemically induced mammary carcinogenesis. Cancer Prev Res (Phila). 2009;2(4):338–44.

    CAS  Google Scholar 

  82. Zhu Z, Jiang W, Zacher JH, Neil ES, McGinley JN, Thompson HJ. Effects of energy restriction and wheel running on mammary carcinogenesis and host systemic factors in a rat model. Cancer Prev Res (Phila). 2012;5(3):414–22.

    CAS  Google Scholar 

  83. Gueritat J, Lefeuvre-Orfila L, Vincent S, Cretual A, Ravanat JL, Gratas-Delamarche A, et al. Exercise training combined with antioxidant supplementation prevents the antiproliferative activity of their single treatment in prostate cancer through inhibition of redox adaptation. Free Radic Biol Med. 2014;77:95–105.

    CAS  PubMed  Google Scholar 

  84. Isanejad A, Alizadeh AM, Amani Shalamzari S, Khodayari H, Khodayari S, Khori V, et al. MicroRNA-206, let-7a and microRNA-21 pathways involved in the anti-angiogenesis effects of the interval exercise training and hormone therapy in breast cancer. Life Sci. 2016;151:30–40.

    CAS  PubMed  Google Scholar 

  85. Figueira ACC, Figueira MC, Silva C, Padrão A, Oliveira PA, Ferreira RP, et al. Exercise training-induced modulation in microenvironment of rat mammary neoplasms. Int J Sports Med. 2018;39(12):885–92.

    PubMed  Google Scholar 

  86. Martin F, Ladoire S, Mignot G, Apetoh L, Ghiringhelli F. Human FOXP3 and cancer. Oncogene. 2010;29(29):4121–9.

    CAS  PubMed  Google Scholar 

  87. Malaguarnera R, Belfiore A. The insulin receptor: a new target for cancer therapy. Front Endocrinol (Lausanne). 2011;2:93.

    Google Scholar 

  88. Il'yasova D, et al. Circulating levels of inflammatory markers and cancer risk in the health aging and body composition cohort. Cancer Epidemiol Biomark Prev. 2005;14(10):2413–8.

    CAS  Google Scholar 

  89. Goossens N, Nakagawa S, Sun X, Hoshida Y. Cancer biomarker discovery and validation. Transl Cancer Res. 2015;4(3):256–69.

    CAS  PubMed  Google Scholar 

  90. Carli F, Brown R, Kennepohl S. Prehabilitation to enhance postoperative recovery for an octogenarian following robotic-assisted hysterectomy with endometrial cancer. Can J Anaesth. 2012;59(8):779–84.

    PubMed  Google Scholar 

  91. Pamoukdjian F, Bouillet T, Lévy V, Soussan M, Zelek L, Paillaud E. Prevalence and predictive value of pre-therapeutic sarcopenia in cancer patients: a systematic review. Clin Nutr. 2018;37(4):1101–13.

    PubMed  Google Scholar 

  92. Huisman MG, et al. "Timed Up & Go": a screening tool for predicting 30-day morbidity in onco-geriatric surgical patients? A multicenter cohort study. PLoS One. 2014;9(1):e86863.

    PubMed  Google Scholar 

  93. Einstein DJ, Patil D, Chipman J, Regan MM, Davis K, Crociani CM, et al. Expanded Prostate Cancer Index Composite-26 (EPIC-26) online: validation of an internet-based instrument for assessment of health-related quality of life after treatment for localized prostate Cancer. Urology. 2019;127:53–60.

    PubMed  Google Scholar 

  94. Wu HH, Lin WC, Tsai KW. Advances in molecular biomarkers for gastric cancer: miRNAs as emerging novel cancer markers. Expert Rev Mol Med. 2014;16:e1.

    PubMed  PubMed Central  Google Scholar 

  95. Volckmar AL, Sültmann H, Riediger A, Fioretos T, Schirmacher P, Endris V, et al. A field guide for cancer diagnostics using cell-free DNA: from principles to practice and clinical applications. Genes Chromosom Cancer. 2018;57(3):123–39.

    CAS  PubMed  Google Scholar 

  96. Fabisiewicz A, Grzybowska E. CTC clusters in cancer progression and metastasis. Med Oncol. 2017;34(1):12.

    PubMed  Google Scholar 

  97. Ferreira V, Agnihotram RV, Bergdahl A, van Rooijen SJ, Awasthi R, Carli F, et al. Maximizing patient adherence to prehabilitation: what do the patients say? Support Care Cancer. 2018;26(8):2717–23.

    PubMed  Google Scholar 

  98. Abelson JS, Chait A, Shen MJ, Charlson M, Dickerman A, Yeo HL. Sources of distress among patients undergoing surgery for colorectal cancer: a qualitative study. J Surg Res. 2018;226:140–9.

    PubMed  Google Scholar 

  99. Lakoski SG, Willis BL, Barlow CE, Leonard D, Gao A, Radford NB, et al. Midlife cardiorespiratory fitness, incident cancer, and survival after cancer in men: the cooper center longitudinal study. JAMA Oncol. 2015;1(2):231–7.

    PubMed  PubMed Central  Google Scholar 

  100. Farrell SW, Cortese GM, LaMonte MJ, Blair SN. Cardiorespiratory fitness, different measures of adiposity, and cancer mortality in men. Obesity (Silver Spring). 2007;15(12):3140–9.

    Google Scholar 

  101. Peel JB, et al. A prospective study of cardiorespiratory fitness and breast cancer mortality. Med Sci Sports Exerc. 2009;41(4):742–8.

    PubMed  PubMed Central  Google Scholar 

  102. Njajou OT, et al. Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study. J Gerontol A Biol Sci Med Sci. 2009;64(8):860–4.

    PubMed  Google Scholar 

  103. Njajou OT, Kanaya AM, Holvoet P, Connelly S, Strotmeyer ES, Harris TB, et al. Association between oxidized LDL, obesity and type 2 diabetes in a population-based cohort, the health, aging and body composition study. Diabetes Metab Res Rev. 2009;25(8):733–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  104. Kamb A. Cell-cycle regulators and cancer. Trends Genet. 1995;11(4):136–40.

    CAS  PubMed  Google Scholar 

  105. Aronis KN, Wang N, Phillips CL, Benjamin EJ, Marcus GM, Newman AB, et al. Associations of obesity and body fat distribution with incident atrial fibrillation in the biracial health aging and body composition cohort of older adults. Am Heart J. 2015;170(3):498–505 e2.

    PubMed  PubMed Central  Google Scholar 

  106. • Cormie P, et al. The impact of exercise on cancer mortality, recurrence, and treatment-related adverse effects. Epidemiol Rev. 2017;39(1):71–92. This systematic review of 36 studies found that patients who performed little/no exercise following cancer diagnosis had a higher risk of cancer mortality and had more adverse effects than those that exercised with greater intensity, volume, or frequency.

    PubMed  Google Scholar 

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  1. Department of Population Sciences, City of Hope, Duarte, CA, 91010, USA

    Kyuwan Lee

  2. Division of Biokinesiology and Physical Therapy, Ostrow School of Dentistry, University of Southern California (USC), Los Angeles, CA, 90089, USA

    Judy Zhou & Christina Chow

  3. Division of Populations Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 375 Longwood Ave, Boston, MA, 02215, USA

    Mary K. Norris & Christina M. Dieli-Conwright

Authors
  1. Kyuwan Lee
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  2. Judy Zhou
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  3. Mary K. Norris
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  4. Christina Chow
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  5. Christina M. Dieli-Conwright
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Contributions

Conception and design of the study: all authors; drafting the article or revising it critically for important intellectual content: all authors; final approval of the version to be submitted: Christina Dieli-Conwright.

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Correspondence to Christina M. Dieli-Conwright.

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Conflict of Interest

Kyuwan Lee, Judy Zhou, Mary K. Norris, Christina Chow, and Christina M. Dieli-Conwright declare they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Kyuwan Lee and Judy Zhou are co-first authors.

This article is part of the Topical Collection on Cardio-oncology

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Lee, K., Zhou, J., Norris, M.K. et al. Prehabilitative Exercise for the Enhancement of Physical, Psychosocial, and Biological Outcomes Among Patients Diagnosed with Cancer. Curr Oncol Rep 22, 71 (2020). https://doi.org/10.1007/s11912-020-00932-9

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  • DOI: https://doi.org/10.1007/s11912-020-00932-9

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