Emerging Therapies in Metastatic Prostate Cancer
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Purpose of Review
In the last decade, there have been multiple landmark therapeutic advances for the treatment of metastatic prostate cancer, both in the castration-resistant and hormone-sensitive setting. In this review, we highlight recent progress and ongoing trials for metastatic prostate cancer, including advances in chemotherapy, androgen receptor-directed therapy, targeted therapies, and immunotherapy.
Several landmark studies for men with metastatic hormone-sensitive prostate cancer demonstrated improvement in overall survival with the addition of docetaxel chemotherapy or abiraterone acetate to standard androgen deprivation therapy. A single-arm phase 2 study of the PARP inhibitor olaparib demonstrated high response rates and more favorable progression-free and overall survival for men with metastatic castration-resistant prostate cancer and DNA repair defects treated with olaparib compared with men without DNA repair defects. Multiple ongoing clinical trials are investigating novel hormonal therapies and combinations of chemotherapy, targeted small molecules, immunotherapy, and radiopharmaceuticals.
Progress continues to be made in the treatment of metastatic prostate cancer, and ongoing clinical trials continue to investigate novel agents and approaches to treatment.
KeywordsMetastatic hormone-sensitive prostate Cancer Metastatic castration-resistant prostate Cancer Chemohormonal therapy Hormonal therapy Targeted small molecules Immunotherapy Radiopharmaceuticals Targeting DNA repair defects
Compliance with Ethical Standards
Conflict of Interest
Daniel Sonnenburg declares that he has no conflict of interest.
Alicia Morgans has received compensation from Genentech, Bayer, and AztraZeneca for participation on advisory boards, and has received compensation from Janssen for service as a consultant.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance
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