Targeted Agents in Cervical Cancer: Beyond Bevacizumab

  • Gloria Marquina
  • Aranzazu Manzano
  • Antonio Casado
Gynecologic Cancers (NS Reed, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Gynecologic Cancers


Cervical cancer constitutes a leading cause of morbidity and cancer deaths in women throughout the world. Approximately two thirds of the patients are diagnosed with locally advanced cervical cancer, showing disappointing survival rates despite correct multidisciplinary management. Metastatic disease implies a poor prognosis itself since diagnosis. Platinum-based chemotherapy has been the backbone treatment of metastatic cervical cancer for years with no major outstanding improvements on survival. The addition of new molecules, such as antiangiogenic agents, dramatically changed the treatment of this disease. Bevacizumab, an antiangiogenic agent that targets vascular endothelial growth factor 2 (VEGF-2), added to standard chemotherapy in cervical cancer showed significant improvement on survival; therefore, the combination of carboplatin, paclitaxel, and bevacizumab is currently the standard frontline treatment in cervical cancer. Other antiangiogenic agents have been tested in this disease with no further development nor approvals. New compounds are currently being under development with promising results in this disease as well as a number of new strategies that could potentially fulfill the unmet need of establishing effective therapeutic approaches in cervical cancer.


Cervical carcinoma Advanced disease Bevacizumab Antiangiogenic Targeted therapy Targeted agents Immunotherapy Novel agents 


Compliance with Ethical Standards

Conflict of Interest

Gloria Marquina, Arancha Manzano, and Antonio Casado declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as:• Of importance •• Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Gloria Marquina
    • 1
  • Aranzazu Manzano
    • 1
  • Antonio Casado
    • 1
    • 2
  1. 1.Department of Medical OncologyHospital Universitario San CarlosMadridSpain
  2. 2.Complutense UniversityMadridSpain

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