Melanoma and Immune Checkpoint Inhibitors

  • Masutaka Furue
  • Takamichi Ito
  • Naoko Wada
  • Maiko Wada
  • Takafumi Kadono
  • Hiroshi Uchi
Melanoma (RJ Sullivan, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Melanoma


Purpose of Review

Prognosis of patients with advanced melanoma is dismal with a median overall survival of about 8 months and 5-year overall survival from a diagnosis of metastatic disease of roughly 10%. However, immune checkpoint inhibitors have brought indispensable benefits to melanoma patients. Here we will review the recent clinical efficacy and adverse events of immune checkpoint inhibitors for melanoma patients.

Recent Findings

The immune checkpoint inhibitors increase confirmed objective response and prolong progression-free and overall survival of the afflicted patients in association with maintaining their quality of life. Although diverse immune-related adverse events occur, most of them are manageable by appropriate immunomodulating agents. Clinical efficacy of immune checkpoint inhibitors continues even after discontinuation of drugs.


Compared with conventional therapeutic options, the immune checkpoint inhibitors appear to prolong the survival of patients with advanced melanoma. Further clinical trials are warranted to determine whether their combinatory use with other treatment options may augment benefits or not.


Melanoma Immune checkpoint inhibitors Ipilimumab Nivolumab Pembrolizumab 


Compliance with Ethical Standards

Conflict of Interest

Masutaka Furue, Takamichi Ito, Naoko Wada, Maiko Wada, Takafumi Kadono, and Hiroshi Uchi declare they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Masutaka Furue
    • 1
  • Takamichi Ito
    • 1
  • Naoko Wada
    • 1
  • Maiko Wada
    • 1
  • Takafumi Kadono
    • 2
  • Hiroshi Uchi
    • 1
  1. 1.Department of DermatologyKyushu UniversityFukuokaJapan
  2. 2.Department of DermatologySt. Marianna University School of MedicineKawasakiJapan

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