Current Information and Recommendations on the Discontinuation of TKI Inhibitors in Chronic Myeloid Leukemia

  • Massimo Breccia
  • Robin Foà
Leukemia (A Aguayo, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Leukemia


Purpose of Review

Discontinuation of tyrosine kinase inhibitors (TKIs) in chronic phase chronic myeloid leukemia (CP-CML) patients has become a reality. Treatment-free remission (TFR) is the term that identifies success after discontinuation.

Recent Findings

Several trials have demonstrated that with imatinib about 40% of patients discontinuing treatment in deep and stable molecular response remain disease-free. Second-generation TKIs have improved the rate of deep molecular responses and allowed to increase the percentage of patients attempting treatment discontinuation.


We hereby review the current information based on the available published data and discuss the current suggestions on how to move TFR into the clinical practice.


Chronic myeloid leukemia Tyrosine kinase inhibitors Discontinuation Treatment-free remission 


Compliance with Ethical Standards

Conflict of Interest

Massimo Breccia has received compensation from Pfizer, Bristol-Myers Squibb, Incyte, and Novartis for service as a consultant.

Robin Foà has received compensation from Janssen, Gilead, Roche, Celgene, Amgen, AbbVie, Novartis, and Sandoz for service on advisory boards and/or speaker’s bureaus.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Hematology, Department of Cellular Biotechnologies and Hematology, Policlinico Umberto 1‘Sapienza’ UniversityRomeItaly

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