Current Information and Recommendations on the Discontinuation of TKI Inhibitors in Chronic Myeloid Leukemia
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Purpose of Review
Discontinuation of tyrosine kinase inhibitors (TKIs) in chronic phase chronic myeloid leukemia (CP-CML) patients has become a reality. Treatment-free remission (TFR) is the term that identifies success after discontinuation.
Several trials have demonstrated that with imatinib about 40% of patients discontinuing treatment in deep and stable molecular response remain disease-free. Second-generation TKIs have improved the rate of deep molecular responses and allowed to increase the percentage of patients attempting treatment discontinuation.
We hereby review the current information based on the available published data and discuss the current suggestions on how to move TFR into the clinical practice.
KeywordsChronic myeloid leukemia Tyrosine kinase inhibitors Discontinuation Treatment-free remission
Compliance with Ethical Standards
Conflict of Interest
Massimo Breccia has received compensation from Pfizer, Bristol-Myers Squibb, Incyte, and Novartis for service as a consultant.
Robin Foà has received compensation from Janssen, Gilead, Roche, Celgene, Amgen, AbbVie, Novartis, and Sandoz for service on advisory boards and/or speaker’s bureaus.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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