Management of Gynecological Cancers During Pregnancy
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The diagnosis of a gynecological malignancy during pregnancy is rare but not uncommon. Cancer treatment during pregnancy is possible, but both maternal and fetal interests need to be respected. Different treatment plans may be justifiable and multidisciplinary treatment is advised. Clinical trials are virtually impossible, and current evidence is mainly based on small case series and expert opinion. Individualization of treatment is necessary and based on tumor type, stage, and gestational age at time of diagnosis. Termination of pregnancy is not necessary in most cases. Surgery and chemotherapy (second trimester and onwards) are possible types of treatment during pregnancy. Radiotherapy of the pelvic area is not compatible with an ongoing pregnancy. This article discusses the current recommendations for the management of gynecological malignancies (cervical, ovarian, and vulvar cancers) during pregnancy.
KeywordsGynecologic Pregnancy Chemotherapy Surgery Cervical Ovarian Vulvar Cancer
FA is senior clinical researcher for the Research Fund Flanders (F.W.O.). This research is supported by the Research Fund Flanders (F.W.O.), the Belgian Cancer Plan, Ministry of Health, Belgium, and the Clinical Research Fund UZ Leuven (KOF). The authors are grateful to Marie-Astrid Van Hoorick for the administrative support.
Compliance with Ethics Guidelines
Conflict of Interest
Sileny N. Han, Magali Verheecke, Tineke Vandenbroucke, Mina Mhallem Gziri, Kristel Van Calsteren, and Frédéric Amant declare that they have no conflict of interest
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
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