Treating Immune-Related Epilepsy

Epilepsy (CW Bazil, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Epilepsy


Purpose of Review

This review explores different treatment modalities for immune-mediated epilepsy, including epilepsy caused by autoantibodies as well as epilepsy in the context of systemic autoimmune disease.

Recent Findings

Autoimmune epilepsy is an increasingly recognized entity. Conventional treatments for epilepsy, such as antiseizure medications and epilepsy surgery, are less successful in treating epilepsy caused by autoimmune disease. Immunomodulatory therapies such as corticosteroids, intravenous immunoglobulin, and plasma exchange are generally more successful in treating immune-mediated epilepsy than conventional epilepsy therapies.


Autoimmune epilepsy should be considered as a possible etiology for patients with frequent seizures of unknown etiology. The response to immunotherapies is often promising, particularly in patients with antibodies to neuronal cell surface antigens.


Autoimmune epilepsy Encephalitis Treatment Immunotherapy 


Compliance with Ethical Standards

Conflict of Interest

Sonal Bhatia declares no conflict of interest.

Sarah E. Schmitt has received personal fees from SAGE Therapeutics.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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Authors and Affiliations

  1. 1.Department of NeurologyMedical University of South CarolinaCharlestonUSA
  2. 2.Medical University of South CarolinaCharlestonUSA

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