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Self-Collection and Molecular Diagnosis for Detection of Human Papillomavirus: Why Incorporate It?

  • Female Genital Tract Infections (J Sobel, Section Editor)
  • Published:
Current Infectious Disease Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Cervical cancer, the third cause of death by cancer among Brazil’s women, is associated with human papillomavirus (HPV) infection. In some countries of South America, North America, Europe, and Oceania, initial screening for HPV DNA and subsequent follow-up with HPV-positive patients using colposcopy and cytological testing are used as preventative measures.

Recent Findings

For HPV DNA detection, it is necessary to obtain cervical cells by conventional clinical collection method or self-collection of the cells that flake off from the uterine cervix and vaginal canal. Self-collection has been shown to be a viable option for obtaining samples and is a less invasive method that is more accepted by women. Thus, it can potentially decrease the limitations of the conventional clinical collection methods.

Summary

The efficiency of the self-collection method aligned with the implementation of HPV molecular testing, if adopted by public and private health care systems, may extend the reach of current cervical cancer prevention efforts. In addition, considering all phases from triage to treatment, this method may reduce health care costs and the time spent by patients and health care teams to conduct examinations and collect samples.

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Authors and Affiliations

  1. Postgraduate Program of Infectious and Parasitary Diseases from Medicine School, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil

    Larissa Zatorre Almeida-Lugo & Camila Mareti Bonin-Jacob

  2. Bioscience Institute from Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil

    Camila Mareti Bonin-Jacob & Inês Aparecida Tozetti

  3. Medicine School, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil

    Vanessa Terezinha Gubert de Matos

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  1. Larissa Zatorre Almeida-Lugo
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  2. Camila Mareti Bonin-Jacob
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  4. Inês Aparecida Tozetti
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Corresponding author

Correspondence to Vanessa Terezinha Gubert de Matos.

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Conflict of Interest

Larissa Zatorre Almeida-Lugo, Camila Mareti Bonin-Jacob, Vanessa Terezinha Gubert de Matos, and Inês Aparecida Tozetti declare they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Female Genital Tract Infections

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Almeida-Lugo, L.Z., Bonin-Jacob, C.M., de Matos, V.T.G. et al. Self-Collection and Molecular Diagnosis for Detection of Human Papillomavirus: Why Incorporate It?. Curr Infect Dis Rep 21, 13 (2019). https://doi.org/10.1007/s11908-019-0674-9

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  • DOI: https://doi.org/10.1007/s11908-019-0674-9

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