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Innate and Innate-Like Immune System in Hypertension and Vascular Injury

  • Inflammation and Cardiovascular Diseases (A. Kirabo, Section Editor)
  • Published:
Current Hypertension Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

To describe the important role played by innate and innate-like immunity in the pathophysiology of hypertension and vascular injury.

Recent Findings

Innate immune cells, such as neutrophils, dendritic cells, myeloid-derived suppressor cells, and monocytes/macrophages and innate lymphoid cells such as natural killer cells and unconventional T lymphocytes like γδ T cells contribute to hypertensive mechanisms by priming adaptive immune cells, leading to the triggering of vascular inflammation and blood pressure elevation or alternatively protecting against vascular injury. Specifically, monocyte/macrophages and γδ T cells seem to play a crucial role in the initiation of hypertension via regulation of adaptive immunity.

Summary

Innate and innate-like immunity play a leading role in the pathophysiology of hypertension. Recent advances in this field provide us clues for future therapeutic approaches.

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Abbreviations

B7:

Co-stimulatory molecule on antigen-presenting cell surface (CD80 or CD86)

CD28:

Cluster of differentiation 28

CNS:

Central nervous system

MHC II:

Major histocompatibility complex II

TCR:

T cell receptor

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Funding

The authors’ work was supported by the Canadian Institutes of Health Research (CIHR) grants 102606 and 123465, CIHR First Pilot Foundation Grant 143348, a Tier 1 Canada Research Chair (CRC) on Hypertension and Vascular Research by the CRC Government of Canada/CIHR Program, by the Canada Fund for Innovation (all to ELS), and by a fellowship to AC (Canadian Vascular Network).

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Authors and Affiliations

  1. Lady Davis Institute for Medical Research, 3755 Côte-Ste-Catherine Rd, Montreal, Quebec, H3T 1E2, Canada

    Akinori Higaki, Antoine Caillon, Pierre Paradis & Ernesto L. Schiffrin

  2. Department of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, 3755 Côte-Ste-Catherine Rd, Montreal, Quebec, H3T 1E2, Canada

    Ernesto L. Schiffrin

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  1. Akinori Higaki
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  2. Antoine Caillon
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  4. Ernesto L. Schiffrin
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Correspondence to Ernesto L. Schiffrin.

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Dr. Schiffrin reports grants from Canadian Institutes of Health Research and Servier France, personal fees from Novartis USA, and Servier Canada, outside the submitted work. The other authors declare no conflicts of interest relevant to this manuscript.

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Higaki, A., Caillon, A., Paradis, P. et al. Innate and Innate-Like Immune System in Hypertension and Vascular Injury. Curr Hypertens Rep 21, 4 (2019). https://doi.org/10.1007/s11906-019-0907-1

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