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The Role of Uric Acid in Preeclampsia: Is Uric Acid a Causative Factor or a Sign of Preeclampsia?

  • Preeclampsia (VD Garovic, Section Editor)
  • Published:
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Abstract

Purpose of Review

Because of the significant discrepancies on this topic, this review will focus on the role of uric acid in PE, uric acid as a predictor of preeclampsia and fetal growth retardation. We considered eligible review and original articles relevant to the research question.

Recent Findings

Hypertensive disorders of pregnancy such as preeclampsia (PE) are a major cause of both maternal and fetal morbidity and mortality worldwide. Uric acid has been reported as a key factor contributing to the pathogenesis of PE. Some studies have indicated that serum uric acid levels increase with the severity of PE, while several studies have shown contradictory results. Some studies suggested high uric acid levels lead to PE, while others state that PE causes an increase in uric acid levels.

Summary

Despite the strong association of uric acid in the pathogenesis of preeclampsia, current data is still contradictory hence genetic and high-end laboratory investigations may clarify this enigma.

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Authors and Affiliations

  1. Optics and Imaging Centre, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

    Olive P. Khaliq & Thajasvarie Naicker

  2. Third Department of Internal Medicine, University of Fukui Faculty of Medicine Sciences, Fukui, Japan

    Tadashi Konoshita

  3. Department of Obstetrics and Gynaecology and Women’s Health and HIV Research Group, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

    Jagidesa Moodley

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  1. Olive P. Khaliq
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  2. Tadashi Konoshita
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Khaliq, O.P., Konoshita, T., Moodley, J. et al. The Role of Uric Acid in Preeclampsia: Is Uric Acid a Causative Factor or a Sign of Preeclampsia?. Curr Hypertens Rep 20, 80 (2018). https://doi.org/10.1007/s11906-018-0878-7

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