Role of Thioredoxin in Age-Related Hypertension

  • Kumuda C. Das
  • Venkatesh Kundumani-Sridharan
  • Jaganathan Subramani
Hypertension and Obesity (E Reisin, Section Editor)
  • 18 Downloads
Part of the following topical collections:
  1. Topical Collection on Hypertension and Obesity

Abstract

Purpose of Review

Although the roles of oxidant stress and redox perturbations in hypertension have been the subject of several reviews, role of thioredoxin (Trx), a major cellular redox protein in age-related hypertension remains inadequately reviewed. The purpose of this review is to bring readers up-to-date with current understanding of the role of thioredoxin in age-related hypertension.

Recent Findings

Age-related hypertension is a major underlying cause of several cardiovascular disorders, and therefore, intensive management of blood pressure is indicated in most patients with cardiovascular complications. Recent studies have shown that age-related hypertension was reversed and remained lowered for a prolonged period in mice with higher levels of human Trx (Trx-Tg). Additionally, injection of human recombinant Trx (rhTrx) decreased hypertension in aged wild-type mice that lasted for several days. Both Trx-Tg and aged wild-type mice injected with rhTrx were normotensive, showed increased NO production, decreased arterial stiffness, and increased vascular relaxation. These studies suggest that rhTrx could potentially be a therapeutic molecule to reverse age-related hypertension in humans. The reversal of age-related hypertension by restoring proteins that have undergone age-related modification is conceptually novel in the treatment of hypertension.

Summary

Trx reverses age-related hypertension via maintaining vascular redox homeostasis, regenerating critical vasoregulatory proteins oxidized due to advancing age, and restoring native function of proteins that have undergone age-related modifications with loss-of function. Recent studies demonstrate that Trx is a promising molecule that may ameliorate or reverse age-related hypertension in older adults.

Keywords

Hypertension Thioredoxin Age Redox Glutathionylation eNOS 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare no conflicts of interest relevant to this manuscript. A patent application (US 5/323,545 UT Health Sciences Center at Tyler) for use of Thioredoxin in the treatment of high blood pressure is currently pending with the US patent and Trademark Office.

Human and Animal Rights and Informed Consent

This article does not contain any studies with humans or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Kumuda C. Das
    • 1
  • Venkatesh Kundumani-Sridharan
    • 1
  • Jaganathan Subramani
    • 1
  1. 1.Department of Translational and Vascular BiologyUniversity of Texas Health Sciences Center at TylerTylerUSA

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