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New Therapeutic Approaches to Resistant Hypertension

Abstract

Resistant hypertension is a common and growing clinical problem characterized by failure to achieve target blood pressure levels despite adequate use of at least three antihypertensive agents. Although numerous safe and effective pharmacologic therapies are available to treat elevated blood pressure, novel therapeutic approaches are warranted to improve the management and prognosis of patients with resistant hypertension. In this context, several lines of research have generated promising results based on both novel pharmacologic and device-based approaches that may more effectively treat resistant hypertension and its adverse consequences in the future.

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Disclosure

Dr. Schlaich, Dr. Krum, and Dr. Esler are principal investigators in clinical trials sponsored by Ardian, Inc. (NCT00483808 and NCT00551304 at http://ClinicalTrials.gov). Dr. Schlaich and Dr. Esler are supported by Senior Research Fellowships from the National Health & Medical Research Council (NHMRC) of Australia.

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Correspondence to Markus P. Schlaich.

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Schlaich, M.P., Krum, H. & Esler, M.D. New Therapeutic Approaches to Resistant Hypertension. Curr Hypertens Rep 12, 296–302 (2010). https://doi.org/10.1007/s11906-010-0119-1

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Keywords

  • Resistant hypertension
  • Therapy
  • Renin
  • Aldosterone
  • Sympathetic
  • Renal nerves
  • Baroreflex