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New Therapeutic Approaches to Resistant Hypertension

Current Hypertension Reports volume 12, pages 296–302 (2010)Cite this article

Abstract

Resistant hypertension is a common and growing clinical problem characterized by failure to achieve target blood pressure levels despite adequate use of at least three antihypertensive agents. Although numerous safe and effective pharmacologic therapies are available to treat elevated blood pressure, novel therapeutic approaches are warranted to improve the management and prognosis of patients with resistant hypertension. In this context, several lines of research have generated promising results based on both novel pharmacologic and device-based approaches that may more effectively treat resistant hypertension and its adverse consequences in the future.

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Disclosure

Dr. Schlaich, Dr. Krum, and Dr. Esler are principal investigators in clinical trials sponsored by Ardian, Inc. (NCT00483808 and NCT00551304 at http://ClinicalTrials.gov). Dr. Schlaich and Dr. Esler are supported by Senior Research Fellowships from the National Health & Medical Research Council (NHMRC) of Australia.

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Authors and Affiliations

  1. Neurovascular Hypertension & Kidney Disease Laboratory, Baker IDI Heart & Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria, 8008, Australia

    Markus P. Schlaich & Murray D. Esler

  2. Monash Centre of Cardiovascular Research & Education in Therapeutics, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia

    Henry Krum

Authors
  1. Markus P. Schlaich
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  2. Henry Krum
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Correspondence to Markus P. Schlaich.

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Schlaich, M.P., Krum, H. & Esler, M.D. New Therapeutic Approaches to Resistant Hypertension. Curr Hypertens Rep 12, 296–302 (2010). https://doi.org/10.1007/s11906-010-0119-1

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Keywords

  • Resistant hypertension
  • Therapy
  • Renin
  • Aldosterone
  • Sympathetic
  • Renal nerves
  • Baroreflex