Skip to main content

Advertisement

Log in

The Association Between Marijuana Use and HIV Continuum of Care Outcomes: a Systematic Review

  • Behavioral Bio-Medical Interface (JL Brown and RJ DiClemente, Section Editors)
  • Published:
Current HIV/AIDS Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Approximately 77% of HIV-infected adults report lifetime marijuana use. Given the high rates and social acceptability of marijuana use among HIV-infected individuals, it is important to gain a stronger understanding of if, and how, marijuana impacts HIV care cascade outcomes. The purpose of this study is to systematically review recent articles that assess the relationship between marijuana use and HIV continuum of care outcomes.

Recent Findings

One hundred and ninety articles from PubMed were considered for inclusion, and 15 were included in the review. The studies focus on marijuana use among HIV-infected individuals aware of their serostatus (k = 4), individuals engaged in treatment (k = 1), marijuana use in association with adherence to antiretroviral medications (k = 6), and marijuana use in relation to multiple stages of the HIV care cascade (k = 4). Preliminary findings from the small number of studies revealed an association between marijuana use, especially current heavy use, and HIV seropositivity. However, results from studies assessing marijuana use and treatment engagement and adherence to antiretroviral medications were inconsistent and inconclusive.

Summary

Additional research is needed to assess the nuanced relationship between marijuana use and HIV continuum of care outcomes, especially among subgroups of HIV-infected individuals, such as men who have sex with men and young adults.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. The Joint United Nations Programme on HIV/AIDS. UNAIDS Data 2017. Geneva: Switzerland; 2017. http://www.unaids.org/sites/default/files/media_asset/20170720_Data_book_2017_en.pdf. Accessed February 2018.

  2. Centers for Disease Control and Prevention. HIV Surveillance Report, 2016; vol. 28. http://www.cdc.gov/hiv/library/reports/hiv-surveillance.html. Published November 2017. Accessed February 2018.

  3. Broz D, Pham H, Spiller M, Wejnert C, Le B, Neaigus A, et al. Prevalence of HIV infection and risk behaviors among younger and older injecting drug users in the United States, 2009. AIDS Behav. 2014;18:284–96. https://doi.org/10.1007/s10461-013-0660-4.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Broz D, Wejnert C, Pham HT, DiNenno E, Heffelfinger JD, Cribbin M, et al. National HIV Behavioral Surveillance System Study Group. MMWR Surveill Summ. 2014;63:1–51.

    PubMed  Google Scholar 

  5. Chinnapaiyan S, Unwalla HJ. Mucociliary dysfunction in HIV and smoked substance abuse. Front Microbiol. 2015;6:1052. https://doi.org/10.3389/fmicb.2015.01052.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Raposeiras-Roubín S, Abu-Assi E, Iñiguez-Romo A. Tobacco, illicit drugs use and risk of cardiovascular disease in patients living with HIV. Curr Opin HIV AIDS. 2017;12:523–7. https://doi.org/10.1097/COH.0000000000000407.

    Article  PubMed  Google Scholar 

  7. Substance Abuse and Mental Health Services Administration, Center for Behavioral Health Statistics and Quality. The NSDUH report: HIV/AIDS and substance use. 2010. Rockville, MD.

  8. • Shiau S, Arpadi SM, Yin MT, Martins SS. Patterns of drug use and HIV infection among adults in a nationally representative sample. Addict Behav. 2017;68:39–44. https://doi.org/10.1016/j.addbeh.2017.01.015. This study used data from the National Survey on Drug Use and Health to highlight the higher prevalence rates of marijuana and other substance use and dependence among HIV-infected individuals relative to their non-infected counterparts.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Quinn K, Voisin DR, Bouris A, Schneider J. Psychological distress, drug use, sexual risks and medication adherence among young HIV-positive Black men who have sex with men: exposure to community violence matters. AIDS Care. 2016;28:866–72. https://doi.org/10.1080/09540121.2016.1153596.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Parsons JT, Starks TJ, Millar BM, Boonrai K, Marcotte D. Patterns of substance use among HIV-positive adults over 50: implications for treatment and medication adherence. Drug Alcohol Depend. 2014;139:33–40. https://doi.org/10.1016/j.drugalcdep.2014.02.704.

    Article  PubMed  PubMed Central  Google Scholar 

  11. • Hartzler B, Dombrowski JC, Crane HM, Eron JJ, Geng EH, Christopher Matthews W, et al. Prevalence and predictors of substance use disorders among HIV care enrollees in the United States. AIDS Behav. 2017;21:1138–48. https://doi.org/10.1007/s10461-016-1584-6. This project focuses on the prevalence and predictors of substance use disorders (e.g., marijuana) among a longitudinal cohort of HIV-infected individuals enrolled in the Centers for AIDS Research Network of Integrated Clinical Systems, a network of affiliated HIV/AIDS urban care sites.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Dʼsouza G, Matson PA, Grady CD, Nahvi S, Merenstein D, Weber KM, et al. Medicinal and recreational marijuana use among HIV-infected women in the Women’s Interagency HIV Study (WIHS) cohort, 1994–2010. J Acquir Immune Defic Syndr. 2012;61:618–26.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Ellis RJ, Toperoff W, Vaida F, van den Brande G, Gonzales J, Gouaux B, et al. Smoked medicinal cannabis for neuropathic pain in HIV: a randomized crossover clinical trial. Neuropsychopharmacology. 2009;34:672–80.

    Article  PubMed  CAS  Google Scholar 

  14. Lutge EE, Gray A, Siegfried N. The medical use of cannabis for reducing morbidity and mortality in patients with HIV/AIDS. Cochrane Database Syst Rev. 2013;4:CD005175.

    Google Scholar 

  15. Volkow ND, Baler RD, Compton WM, Weiss SRB. Adverse health effects of marijuana use. New Eng J Med. 2014;370:2219–27.

    Article  PubMed  CAS  Google Scholar 

  16. Cristiani SA, Pukay-Martin ND, Bornstein RA. Marijuana use and cognitive function in HIV-infected people. J Neuropsychiatr Clin Neurosci. 2004;16:330–5.

    Article  Google Scholar 

  17. • Skalski LM, Towe SL, Sikkema KJ, Meade CS. The impact of marijuana use on memory in HIV-infected patients: a comprehensive review of the HIV and marijuana literatures. Curr Drug Abuse Rev. 2017;9:126–41. This systematic review examines both the literature on memory functioning among HIV-infected individuals and memory functioning in marijuana users. The review synthesizes information from both of these areas to inform future research directions on the link between marijuana and memory-functioning among HIV-infected individuals.

    Article  PubMed Central  CAS  Google Scholar 

  18. Mugavero MJ, Amico KR, Horn T, Thompson MA. The state of engagement in HIV care in the United States: from cascade to continuum to control. Clin Infect Dis. 2013;57:1164–71.

    Article  PubMed  Google Scholar 

  19. Joint United Nations Programme on HIV/AIDS (UNAIDS). 90-90-90: an ambitious treatment target to help end the AIDS epidemic. Geneva, 2014.

  20. US Government. National HIV/AIDS Strategy for the United States. 2010; http://www.whitehouse.gov/sites/default/files/uploads/NHAS.pdf. Accessed February 2018.

  21. Gardner EM, McLees MP, Steiner JF, del Rio C, Burman WJ. The spectrum of engagement in HIV care and its relevance to test-and-treat strategies for prevention of HIV infection. Clin Infect Dis. 2011;52:793–800.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Esposito-Smythers C, Brown LK, Wolff J, Xu J, Thornton S, Tidey J, et al. Substance abuse treatment for HIV infected young people: an open pilot trial. J Subst Abus Treat. 2014;46:244–50.

    Article  Google Scholar 

  23. Brown SA, Myers MG, Lippke L, Tapert SF, Stewart DG, Vik PW. Psychometric evaluation of the Customary Drinking and Drug Use Record (CDDR): a measure of adolescent alcohol and drug involvement. J Stud Alcohol. 1998;59(4):427–38.

    Article  PubMed  CAS  Google Scholar 

  24. Reback CJ, Fletcher JB. Reductions in HIV prevalence rates among substance-using men who have sex with men in Los Angeles County, 2008–2011. AIDS Educ Prev. 2014;26:459–70.

    Article  PubMed  Google Scholar 

  25. Adams JW, Bryant KJ, Edelman JE, Fiellin DA, Gaither JR, Gordon AJ, et al. Association of cannabis, stimulant, and alcohol use with mortality prognosis among HIV-infected men. AIDS Behav. 2018;22:1341–51.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Keen L, Abbate A, Blanden G, Priddie C, Moeller FG, Rathmore M. Confirmed marijuana use and lymphocyte count in black people living with HIV. Drug Alcohol Depend. 2017;180:22–5.

    Article  PubMed  Google Scholar 

  27. Kipp AM, Rebeiro PF, Shepard BE, Brinkley-Rubinstein L, Turner M, Bebawy S, et al. Daily marijuana use is associated with missed clinic appointments among HIV-infected persons engaged in HIV care. AIDS Behav. 2017;21:1996–2004.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Attonito J, Devieux JG, Lerner BD, Hospital MM, Rosenberg R. Antiretroviral treatment adherence as a mediating factor between psychosocial variables and HIV viral load. J Assoc Nurses AIDS Care. 2014;25:626–537.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Newville H, Berg KM, Gonzalez JS. The interaction of active substance use, depression, and antiretroviral adherence in methadone maintenance. Int J Behav Med. 2015;22:214–22.

    Article  PubMed  Google Scholar 

  30. Gross IM, Hosek S, Richards MH, Fernandez MI. Predictors and profiles of antiretroviral therapy adherence among African American adolescents and young adult males living with HIV. AIDS Patient Care STDs. 2016;30:324–38.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Kuhns LM, Hotton AL, Garofalo R, Muldoon AL, Jaffe K, Bouris A, et al. An index of multiple, psychosocial, syndemic conditions is associated with antiretroviral medication adherence among HIV-positive youth. AIDS Patient Care STDs. 2016;30:185–92.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Vidot DC, Lerner B, Gonzalez R. Cannabis use, medication management and adherence among persons living with HIV. AIDS Behav. 2017;21:2005–13.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Zhang Y, Wilson TE, Adedimeji A, Merenstein D, Milam J, Cohen J, et al. The impact of substance use on adherence to antiretroviral therapy among HIV-infected women in the United States. AIDS Behav. 2018;22:896–908.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Morgan E, Khanna AS, Skaathun B, Michaels S, Young L, Duvoisin R, et al. Marijuana use among young Black men who have sex with men and the HIV care continuum: findings from the uConnect cohort. Subst Use Misuse. 2016;51:1751–9.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Hightow-Weidman L, LeGrand S, Choi SK, Egger J, Hurt CB, Muessig KE. Exploring the HIV continuum of care among young Black MSM. PLoS One. 2017;12:e0179688.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  36. Okafor CN, Zhou Z, Burrell LE, Kelso NE, Whitehead NE, Harman JS, et al. Marijuana use and viral suppression in persons receiving medical care for HIV-infection. Am J Drug Alcohol Abuse. 2017;43:103–10.

    Article  PubMed  Google Scholar 

  37. Furler MD, Einarson TR, Millson M, Walmsley S, Bendayan R. Medicinal and recreational marijuana use by patients infected with HIV. AIDS Patient Care STDs. 2004;18(4):215–28.

    Article  PubMed  Google Scholar 

  38. Prentiss D, Power R, Balmas G, Tzuang G, Israelski DM. Patterns of marijuana use among patients with HIV/AIDS followed in a public health care setting. J Acquir Immune Defic Syndr. 2004;35(1):38–45.

    Article  PubMed  Google Scholar 

  39. Corless IB, Lindgren T, Holzemer W, Robinson L, Moezzi S, Kirksey K, et al. Marijuana effectiveness as an HIV self-care strategy. Clin Nurs Res. 2009;18:172–93.

    Article  PubMed  Google Scholar 

  40. de Jong BC, Prentiss D, McFarland W, Machekano R, Israelski DM. Marijuana use and its association with adherence to antiretroviral therapy among HIV-infected persons with moderate to severe nausea. J Acquir Immune Defic Syndr. 2005;38:43–6.

    Article  PubMed  Google Scholar 

  41. Rosen MI, Black AC, Arnsten JH, Goggin K, Remien RH, Simoni JM, et al. Association between use of specific drugs and antiretroviral adherence: Findings from MACH 14. AIDS Behav. 2013;17:142–7.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  42. Haney M, Gunderson EW, Rabkin J, Hart CL, Vosburg SK, Comer SD, et al. Dronabinol and marijuana in HIV-positive marijuana smokers. Caloric intake, mood and sleep. J Acquir Immune Defic Syndr. 2007;45:545–54.

    Article  PubMed  CAS  Google Scholar 

  43. Woolridge E, Barton S, Samuel J, Osorio J, Dougherty A, Holdcroft A. Cannabis use in HIV for pain and other medical symptoms. J Pain Symptom Manag. 2005;29:358–67.

    Article  Google Scholar 

  44. Buckner JD, Heimberg RG, Schmidt NB. Social anxiety and marijuana-related problems: the role of social avoidance. Addict Behav. 2011;36:129–32.

    Article  PubMed  Google Scholar 

  45. Cahill S, Taylor SW, Elsesser SA, Mena L, Hickson D, Mayer KH. Stigma, medical mistrust, and perceived racism may affect PrEP awareness and uptake in Black compared to White gay and bisexual men in Jackson, Mississippi and Boston, Massachusetts. AIDS Care. 2017;29:1351–8.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Eaton LA, Driffin DD, Kegler C, Smith H, Conway-Washington C, White D, et al. The role of stigma and medical mistrust in the routine health care engagement of Black men who have sex with men. Am J Public Health. 2015;105:e75–82.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Costantino CM, Gupta A, Yewdall AW, Dale BM, Devi LA. Chen BK. Cannabinoid-receptor 2-mediated attenuation of CXCR4-tropic HIV infection in primary CD4+ T cells. PLoS One. 2012;7:e33961.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  48. Williams JC, Appelberg S, Goldberger BA, Klein TW, Sleasman JW, Goodenow MM. Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection. J NeuroImmune Pharmacol. 2014;9:369–79.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Abrams DI, Hilton JF, Leiser RJ, Shade SB, Elbeik TA, Aweeka FT, et al. Short term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trial. Ann Intern Med. 2003;139:258–66.

    Article  PubMed  CAS  Google Scholar 

  50. Ghosn J, Leruez-Ville M, Blanche J, Delobelle A, Beaudoux C, Mascard L, et al. HIV-1 DNA levels in peripheral blood mononuclear cells and cannabis use are associated with intermittent HIV shedding in semen of men who have sex with men on successful antiretroviral regimens. Clin Infect Dis. 2014;58:1763–70.

    Article  PubMed  CAS  Google Scholar 

  51. Milloy MJ, Marshall B, Kerr T, Richardson L, Hogg R, Guillemi S, et al. High-intensity cannabis use associated with lower plasma HIV-1 RNA viral load among recently-infected people who use injection drugs. Drug Alcohol Rev. 2015;34:135–40.

    Article  PubMed  Google Scholar 

  52. Thames AD, Kuhn TP, Williamson TJ, Jones JD, Mahmood Z, Hammond A. Marijuana effects on changes in brain structure and cognitive function among HIV+ and HIV-adults. Drug Alcohol Depend. 2017;170:120–7.

    Article  PubMed  CAS  Google Scholar 

Download references

Funding

Effort for this project was supported by NIDA K23DA042130 (PI Montgomery) and NIDA R25DA035163 (Co-PIs Masson & Sorensen).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to LaTrice Montgomery.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Behavioral-Bio-Medical Interface

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Montgomery, L., Bagot, K., Brown, J.L. et al. The Association Between Marijuana Use and HIV Continuum of Care Outcomes: a Systematic Review. Curr HIV/AIDS Rep 16, 17–28 (2019). https://doi.org/10.1007/s11904-019-00422-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11904-019-00422-z

Keywords

Navigation