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Fat Matters: Understanding the Role of Adipose Tissue in Health in HIV Infection

  • HIV Pathogenesis and Treatment (AL Landay, Section Editor)
  • Published:
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Abstract

More than one-third of adults in the USA are obese and obesity-related disease accounts for some of the leading causes of preventable death. Mid-life obesity may be a strong predictor of physical function impairment later in life regardless of body mass index (BMI) in older age, highlighting the benefits of obesity prevention on health throughout the lifespan. Adipose tissue disturbances including lipodystrophy and obesity are prevalent in the setting of treated and untreated HIV infection. This article will review current knowledge on fat disturbances in HIV-infected persons, including therapeutic options and future directions.

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Authors and Affiliations

  1. University of Colorado-Anschutz Medical Center, 12700 E 19th Ave, Mailstop B168, Aurora, CO, USA

    Kristine M. Erlandson

  2. University of California, Los Angeles, 11075 Santa Monica Blvd., Ste. 100, Los Angeles, CA, USA

    Jordan E. Lake

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  1. Kristine M. Erlandson
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Correspondence to Kristine M. Erlandson.

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Conflict of Interest

Kristine M. Erlandson reports grants from NIH and is a recipient of the Gilead Sciences Research Scholars Program in HIV.

Jordan E Lake reports personal fees from Gilead Sciences and GlaxoSmithKline.

Funding

This manuscript was supported through funding from the National Institutes of Health, National Institute on Aging (K23 AG050260 to KM Erlandson) and National Institutes of Allergy and Infectious Diseases (K23 AI110532 to JE Lake).

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on HIV Pathogenesis and Treatment

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Erlandson, K.M., Lake, J.E. Fat Matters: Understanding the Role of Adipose Tissue in Health in HIV Infection. Curr HIV/AIDS Rep 13, 20–30 (2016). https://doi.org/10.1007/s11904-016-0298-8

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