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Global Epidemiology of Drug-Induced Liver Injury (DILI)

  • Drug-Induced Liver Injury (P Hayashi, Section Editor)
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Abstract

Purpose of Review

Drug-induced liver injury (DILI) is not an uncommon liver disease in many parts of the world. DILI is one of the most common causes of acute liver failure in most countries. The current review summarizes the global epidemiology of DILI.

Recent Findings

The number need to harm in terms of DILI due to amoxicillin-clavulanate was approximately 1 out 2300, but was higher for azathioprine (1 out of 133) and infliximab (1 out of 148). A retrospective Chinese study showed the highest rate of DILI in hospitalized patients with an incidence of approximately 24 patients per 100,000 annually with a more favorable prognosis in the DILI cohort than previously reported from Europe, the USA, and Asia.

Summary

Although large DILI registries from Europe and the USA have collected much data, more prospective studies with continual enrollment are needed particularly as new therapies such as immune modulatory and oncological medications with longer half-lives and latencies come to market.

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Authors and Affiliations

  1. Faculty of Medicine, University of Iceland, The National University Hospital of Iceland, Reykjavik, Iceland

    Einar S. Björnsson

  2. Department of Internal Medicine and Division of Gastroenterology and Hepatology, The National University Hospital of Iceland, Reykjavik, Iceland

    Einar S. Björnsson

  3. Faculty of Medicine, The National University Hospital of Iceland, Hringbraut, 101, Reykjavik, Iceland

    Einar S. Björnsson

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Björnsson, E.S. Global Epidemiology of Drug-Induced Liver Injury (DILI). Curr Hepatology Rep 18, 274–279 (2019). https://doi.org/10.1007/s11901-019-00475-z

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