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Impact of Non-alcoholic Fatty Liver Disease on Chronic Hepatitis B Infection

  • Hepatitis B (J Lim, Section Editor)
  • Published:
Current Hepatology Reports Aims and scope Submit manuscript

Abstract

Purpose of review

Both chronic hepatitis B (CHB) and non-alcoholic fatty liver disease (NAFLD) are frequent liver diseases with substantial morbidity and mortality. How often do these two diseases occur together? Does hepatitis B virus protect or promote concurrent fatty liver? How does concurrent fatty liver influence the clinical outcomes of CHB? We summarized the latest evidence to tackle all these clinically significant questions.

Recent findings

Concurrent fatty liver in CHB without significant alcohol intake is a common and increasingly alarming problem. Patients with CHB have a lower chance of fatty liver than the general population, but the underlying mechanism remains to be further explored. Clinical impacts of concurrent fatty liver among CHB patients, in terms of treatment response, fibrosis and cirrhosis progression, liver cancer risk, and mortality, are still debatable.

Summary

Concurrent fatty liver in CHB is a common and clinically relevant condition.

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Authors and Affiliations

  1. Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Anthony W.H. Chan

  2. Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, NT, Hong Kong

    Anthony W.H. Chan, Grace L.H. Wong & Vincent W.S. Wong

  3. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Grace L.H. Wong & Vincent W.S. Wong

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  1. Anthony W.H. Chan
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Correspondence to Anthony W.H. Chan.

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Conflict of Interest

Anthony Chan declares no potential conflict of Interest.

Grace L.H. Wong has served as an advisory committee member for Otsuka and Gilead. She has also served as a speaker for Abbott, Abbvie, Bristol-Myers Squibb, Echosens, Furui, Gilead, Janssen, Otsuka, Roche, and Siemens.

Vincent W.S. Wong has served as an advisory committee member for Abbvie, Roche, Novartis, Gilead, and Otsuka. He has also served as a speaker for Abbvie, Bristol-Myers Squibb, Roche, Novartis, Abbott Diagnostics, and Echosens.

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All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).

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This article is part of the Topical Collection on Hepatitis B

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Chan, A.W., Wong, G.L. & Wong, V.W. Impact of Non-alcoholic Fatty Liver Disease on Chronic Hepatitis B Infection. Curr Hepatology Rep 16, 97–104 (2017). https://doi.org/10.1007/s11901-017-0340-3

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