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Recent Advances in the Biology and Treatment of T Cell Acute Lymphoblastic Leukemia

  • Acute Lymphocytic Leukemias (K Ballen and M Keng, Section Editors)
  • Published:
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Abstract

Purpose of Review

This article provides an overview of the current knowledge regarding the biology and treatment of T cell acute lymphoblastic leukemia (T-ALL) and highlights the most recent findings in this field over the past 5 years.

Recent Findings

Remarkable progress has been made in the genomic landscape of T-ALL over the past few years. The discovery of activating mutations of NOTCH1 and FBXW7 in a majority of patients has been a seminal observation, with several early phase clinical trials currently exploring these as potential therapeutic targets. Characterization of early T cell precursor ALL, incorporation of minimal residual disease assessment into therapeutic protocols, and use of pediatric-intensive regimens along with judicious use of allogeneic HCT have significantly improved risk stratification and treatment outcomes.

Summary

Improved risk stratification and the use of novel targeted therapies based on recent genomic discoveries are expected to change the therapeutic landscape of T-ALL and hopefully improve the outcomes of this historically poor prognosis disease.

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Authors and Affiliations

  1. Division of Hematology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA

    Mehrdad Hefazi & Mark R. Litzow

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  1. Mehrdad Hefazi
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  2. Mark R. Litzow
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Correspondence to Mark R. Litzow.

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This article is part of the Topical Collection on Acute Lymphocytic Leukemias

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Hefazi, M., Litzow, M.R. Recent Advances in the Biology and Treatment of T Cell Acute Lymphoblastic Leukemia. Curr Hematol Malig Rep 13, 265–274 (2018). https://doi.org/10.1007/s11899-018-0455-9

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