Current Hematologic Malignancy Reports

, Volume 13, Issue 2, pp 78–90 | Cite as

Prognostic Factors in the Era of Targeted Therapies in CLL

  • Prajwal Boddu
  • Alessandra Ferrajoli
Chronic Lymphocytic Leukemias (N Jain, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Chronic Lymphocytic Leukemias


Purpose of Review

Chronic lymphocytic leukemia is heterogeneous disease characterized by a variable clinical course that is greatly influenced by various patient and disease characteristics. Over the last two decades, advent of new diagnostic methodologies has led to the identification of several factors of prognostic and predictive relevance. Furthermore, recent advances in next-generation sequencing techniques has identified recurrent novel mutations in NOTCH1, SF3B1, BIRC3, and ATM genes whose role as prognostic and predictive markers is currently being investigated. These biologic markers carry new prognostic information and their incorporation into prognostic scoring systems will likely lead to refined multi-parameter risk models.

Recent Findings

While the prognostic impact of many of the most commonly used markers on clinical outcomes in patients treated with chemo-immunotherapy is well documented, it is important to review their predictive and prognostic role in the era of novel targeted therapies.


This article will discuss the currently available information on the clinical relevance of prognostic markers in patients treated with novel targeted therapies.


Prognostic Chemo-immunotherapy Fludarabine Ibrutinib Idelalisib Venetoclax 


Funding Source

This manuscript was supported in part by the MD Anderson Cancer Centre Leukaemia Support Grant (CCSG) CA016672, the Charif Souki Cancer Research Fund.

Compliance With Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of LeukemiaThe University of Texas M. D. Anderson Cancer CenterHoustonUSA

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