CMV Infection in Pediatric IBD

  • Anat Yerushalmy-Feler
  • Sharona Kern-Isaacs
  • Shlomi Cohen
Pediatric Gastroenterology (S Orenstein, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Pediatric Gastroenterology


Purpose of Review

Patients with inflammatory bowel disease (IBD) are predisposed to infections. Cytomegalovirus (CMV) colitis in adult IBD patients, particularly ulcerative colitis (UC), is related to severe or steroid-refractory disease. The aim of this review is to summarize the data on the prevalence and role of CMV colitis in children with IBD.

Recent Findings

Data on CMV colitis in children continue to be very limited due to its rarity. As in adults, children with coexisting UC and CMV tend to have more severe colitis, are resistant to corticosteroids, and are at high risk for colectomies on short- and long-term follow-up.


In children, as in adults, the significance of CMV colitis, in terms of whether CMV is a pathogen that aggravates acute severe colitis or simply reflects disease severity, is still unknown.


CMV Crohn’s disease Ulcerative colitis IBD Children Adults 


Compliance with Ethical Standards

Conflict of Interest

Anat Yerushalmy-Feler, Sharona Kern-Isaacs, and Shlomi Cohen declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Anat Yerushalmy-Feler
    • 1
    • 2
  • Sharona Kern-Isaacs
    • 2
  • Shlomi Cohen
    • 1
    • 2
  1. 1.Pediatric Gastroenterology Unit, “Dana-Dwek” Children’s HospitalTel Aviv Sourasky Medical CenterTel AvivIsrael
  2. 2.Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael

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