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Issues in Defining the Burden of Prediabetes Globally

  • Diabetes Epidemiology (E Selvin and K Foti, Section Editors)
  • Published:
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Abstract

Purpose of Review

Using a global perspective, this review collates evidence on the heterogeneity of prediabetes definitions and diagnostic methods, their clinical and public health implications, and discusses possible options for improvement.

Recent Findings

Our review notes that the concept of prediabetes is increasingly recognized worldwide, but against a background of non-uniform definition and diagnostic criteria. This results in widely varying burden estimation.

Summary

Current evidence shows a variety of prediabetes phenotypes. This reflects biological and diagnostic heterogeneity, resulting from the use of different tests (glucose or HbA1C) and thresholds to define prediabetes. The biological and diagnostic variabilities have implications for the characterization of the burden of prediabetes, natural history, prognosis, screening, implementation of lifestyle or drug interventions to mitigate related health risks, and monitoring of the effects of such interventions.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital/Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA

    Justin B. Echouffo-Tcheugui

  2. Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa

    Andre P. Kengne

  3. Department of Family and Preventive Medicine, Emory University, Atlanta, GA, USA

    Mohammed K. Ali

  4. Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA

    Mohammed K. Ali

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  1. Justin B. Echouffo-Tcheugui
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  2. Andre P. Kengne
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  3. Mohammed K. Ali
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Correspondence to Justin B. Echouffo-Tcheugui.

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Justin B. Echouffo-Tcheugui, Andre P. Kengne, and Mohammed K Ali declare that they have no conflict of interest.

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This article is part of the Topical Collection on Diabetes Epidemiology

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Echouffo-Tcheugui, J.B., Kengne, A.P. & Ali, M.K. Issues in Defining the Burden of Prediabetes Globally. Curr Diab Rep 18, 105 (2018). https://doi.org/10.1007/s11892-018-1089-y

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