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Treatment of Dyslipidemia in Diabetes: Recent Advances and Remaining Questions

  • Macrovascular Complications in Diabetes (VR Aroda and A Getaneh, Section Editors)
  • Published:
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Abstract

Purpose of Review

This article reviews current knowledge concerning diabetic dyslipidemia and cardiovascular disease (CVD). It reviews strategies to reduce diabetes-associated CVD, including reducing low-density lipoprotein levels, lowering triglycerides, and increasing high-density lipoproteins (HDL). Special considerations, such as the multifactorial chylomicronemia syndrome and partial lipodystrophy, and the role of glucose-lowering strategies in the management of diabetic dyslipidemia are discussed.

Recent Findings

The strongest evidence to date for reducing CVD in diabetes comes from the use of statins. While triglyceride lowering remains inconclusive, an ongoing trial might provide some finality to this question. The role of increasing HDL remains elusive, and HDL cholesterol appears to be an unsatisfactory metric for monitoring therapy.

Summary

The use of statins offers the best current way to reduce diabetes-associated CVD. However, several novel and promising approaches for the management of diabetic dyslipidemia aimed at reducing CVD are in the pipeline.

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Authors and Affiliations

  1. Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA

    Alan Chait

  2. Division of Endocrinology, New York University, New York, NY, USA

    Ira Goldberg

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  1. Alan Chait
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  2. Ira Goldberg
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Correspondence to Alan Chait.

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Conflict of Interest

Alan Chait reports personal fees from Ionis Pharmaceuticals and Merck.

Ira Goldberg reports personal fees from Ionis Pharmaceuticals, Amgen, Merck, and Sanofi/Regeneron.

Human and Animal Rights and Informed Consent

This article contains some studies with human subjects performed by the authors. Informed consent was obtained from all individual participants included in those studies.

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This article is part of the Topical Collection on Macrovascular Complications in Diabetes

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Chait, A., Goldberg, I. Treatment of Dyslipidemia in Diabetes: Recent Advances and Remaining Questions. Curr Diab Rep 17, 112 (2017). https://doi.org/10.1007/s11892-017-0942-8

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