Metabolomics of Diabetic Retinopathy
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Purpose of Review
Metabolomics is the study of dysregulated metabolites in biological materials. We reviewed the use of the technique to elucidate the genetic and environmental factors that contribute to the development of diabetic retinopathy.
With regard to metabolomic studies of diabetic retinopathy, the field remains in its infancy with few studies published to date and little replication of results. Vitreous and serum samples are the main tissues examined, and dysregulation in pathways such as the pentose phosphate pathway, arginine to proline pathway, polyol pathway, and ascorbic acidic pathways have been reported.
Few studies have examined the metabolomic underpinnings of diabetic retinopathy. Further research is required to replicate findings to date and determine longitudinal associations with disease.
KeywordsDiabetic retinopathy Metabolomics Metabonomic Blood Arginine Ascorbic acid
NHMRC Early Career Fellowship Grant APP1073530 to Gerald Liew
Compliance with Ethical Standards
Conflict of Interest
Gerald Liew, Zhou Lei, Nichole Joachim, I-Van Ho, Tien Y. Wong, Paul Mitchell, Bamini Gopinath, and Ben Crossett declare that they have no conflict of interest.
Gavin Tan reports being on the Advisory board for Novartis, travel support from Bayer, research support from Santen, speaker for Abbott Medical, and speaker and travel support from Allergan.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: •Of importance
- 1.Diabetes: facts and figures. 2017. (www.idf.org).