Pharmacological Properties of Faster-Acting Insulin Aspart
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Purpose of Review
Faster aspart is a new formulation of insulin aspart (IAsp) produced by adding the excipients niacinamide and L-arginine. As this new, “ultra-rapid insulin” is available in the EU-market and Canada, the pharmacokinetic and pharmacodynamics data is summarized.
Faster aspart shows an earlier onset of appearance of insulin in the bloodstream after subcutaneous administration and an earlier onset of glucose-lowering action and a higher glycemic effect within the first 30 min. Faster aspart administered by pump is indeed faster than conventional aspart with a faster on (− 11 min), faster off (− 24 min), and more than 100% greater insulin action within the first 30 min. Tolerability of faster aspart is similar to that of Iasp; the same holds true for compatibility in pump use.
Faster aspart shows a faster occurrence of insulin in the blood compared with IAsp in subcutaneous injection. Improvements over current analogs may be more pronounced in pumps than with injections. Data from phase IIIa studies confirm the reduction of postprandial glucose excursions that can be achieved with faster aspart.
KeywordsDiabetes Insulin Pharmacokinetic Pharmacodynamics Faster aspart CSII
Compliance with Ethical Standards
Conflict of Interest
Torben Biester received research support from Medtronic, speaker’s honoraria from Medtronic and Ypsomed, and travel support from Novo Nordisk.
Olga Kordonouri received honoraria for participating on an advisory board of Novo Nordisk as well as speaker’s honoraria from Eli Lilly and Sanofi. She also owns DreaMed stocks.
Thomas Danne reports the following conflicts of interest: AstraZeneca (Speaker, Advisory Panel, Research Support), Boehringer (Speaker, Advisory Panel, Research Support), Bristol-Myers Squibb (Advisory Panel), DexCom (Speaker, Advisory Panel, Research Support), Eli Lilly (Speaker, Advisory Panel, Research Support), Johnson & Johnson (Advisory Panel, Research Support), Medtronic (Speaker, Advisory Panel, Research Support), Novo Nordisk (Speaker, Advisory Panel, Research Support), Roche (Speaker, Advisory Panel, Research Support), Sanofi (Speaker, Advisory Panel, Research Support), Unomedical (Advisory Panel, Research Support), Ypsomed (Speaker, Research Support). Stock Options/Holdings/Board of Directors DreaMed Ltd.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
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