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Stem Cells in Cardiovascular Medicine: the Road to Regenerative Therapies

  • Regenerative Medicine (SM Wu, Section Editor)
  • Published:
Current Cardiology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

The purpose of this review is to provide a broad overview of current trends in stem cell research and its applications in cardiovascular medicine. Researches on different stem cell sources, their inherent characteristics, and the limitations they have in medical applications are discussed. Additionally, uses of stem cells for both modeling and treating cardiovascular disease are discussed, taking note of the obstacles these engineered interventions must overcome to be clinically viable.

Recent Findings

Tissue engineering aims to replace dysfunctional tissues with engineered constructs. Stem cell technologies have been a great enabling factor in working toward this goal.

Summary

Many tissue-engineered products are in development that utilize stem cell technology. Although promising, some refinement must be made to these constructs with respect to safety and functionality. A deeper understanding of basic differentiation and tissue developmental mechanisms is required to allow these engineered tissues to be translated into the clinic.

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Acknowledgments:

This work was supported by 1R01HL116705-01, 1R01HL132130-01, DOD 11959515, and Connecticut’s Regenerative Medicine Research Fund (CRMRF) 12-SCB-YALE-06, 15-RMB-YALE-08 (all to YQ).

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Authors and Affiliations

  1. Vascular Biology and Therapeutics Program, Yale University, New Haven, CT, 06510, USA

    Christopher W. Anderson, Nicole Boardman, Jiesi Luo, Jinkyu Park & Yibing Qyang

  2. Molecular Cell Genetics and Developmental Biology Program, Yale University, New Haven, CT, 06510, USA

    Christopher W. Anderson

  3. Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, Yale School of Medicine, 300 George Street, Ste 773A, New Haven, CT, 06511, USA

    Nicole Boardman, Jiesi Luo, Jinkyu Park & Yibing Qyang

  4. Yale Stem Cell Center, Yale University, New Haven, CT, 06510, USA

    Yibing Qyang

  5. Department of Pathology, Yale University, New Haven, CT, 06510, USA

    Yibing Qyang

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  1. Christopher W. Anderson
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Correspondence to Yibing Qyang.

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Christopher W. Anderson, Nicole Boardman, Jiesi Luo, Jinkyu Park, and Yibing Qyang declare that they have no conflict of interest.

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Anderson, C.W., Boardman, N., Luo, J. et al. Stem Cells in Cardiovascular Medicine: the Road to Regenerative Therapies. Curr Cardiol Rep 19, 34 (2017). https://doi.org/10.1007/s11886-017-0841-2

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