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The Current State of Stem Cell Therapy for Peripheral Artery Disease

  • Peripheral Vascular Disease (MH Shishehbor, Section Editor)
  • Published:
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Abstract

Patients with advanced peripheral arterial disease may develop critical limb ischemia with rest pain, non-healing ulcerations, and eventually may require major amputation despite currently available revascularization technologies. Stem cell therapies hold promise as novel therapeutics to promote vasculogenesis and improve tissue perfusion in these patients. This article reviews the current state of stem cell therapy for patients with peripheral arterial disease, with a focus on the cell types that have been studied, barriers to clinical development, and development of new endpoints for clinical trials.

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Conflict of Interest

Nitin K. Gupta, Ehrin J. Armstrong, and Sahil A. Parikh declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Division of Cardiovascular Medicine, Harrington Heart & Vascular Institute, University Hospitals Case Medical Center, 11000 Euclid Ave., LKS 5038, Cleveland, OH, 44106, USA

    Nitin K. Gupta & Sahil A. Parikh

  2. Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA

    Nitin K. Gupta & Sahil A. Parikh

  3. Division of Cardiology, University of Colorado School of Medicine and VA Eastern Colorado Healthcare System, Denver, CO, USA

    Ehrin J. Armstrong

  4. Division of Cardiovascular Medicine, Harrington Heart & Vascular Institute, University Hospitals Case Medical Center, 11000 Euclid Ave. Lakeside 3019, Cleveland, OH, 44106-5038, USA

    Sahil A. Parikh

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  1. Nitin K. Gupta
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Correspondence to Sahil A. Parikh.

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This article is part of the Topical Collection on Peripheral Vascular Disease

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Gupta, N.K., Armstrong, E.J. & Parikh, S.A. The Current State of Stem Cell Therapy for Peripheral Artery Disease. Curr Cardiol Rep 16, 447 (2014). https://doi.org/10.1007/s11886-013-0447-2

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