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Transcatheter Aortic Valve Replacement: An Update

  • Interventional Cardiology (S Rao, Section Editor)
  • Published:
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Abstract

Aortic stenosis affects many people worldwide with a significant impact on morbidity and mortality with uncorrected, symptomatic aortic valve stenosis carrying mortality of 50 % at one year. Degenerative calcific pathology, the most common cause of aortic stenosis, increases in prevalence with age; estimated prevalence of 5 % in individuals over 75 years of age. Despite the malignant prognosis without valve replacement, many patients are not offered surgery due to advanced age and co-existing medical conditions; reported to be a third of symptomatic patients. In the last several years, transcatheter aortic valve replacement has emerged as an alternative treatment in patients with high or prohibitive open surgical risk. The PARTNER cohort B data, employing the Sapien valve, demonstrated a 20 % absolute mortality benefit at one year compared with medical therapy. In this review, we provide an update of this technology and discuss patient selection, procedural planning, complications, and look toward the future of transcatheter heart valves in the treatment of aortic stenosis.

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Conflict of Interest

Sharif A. Halim declares that he has no conflict of interest.

Todd L. Kiefer declares that he has no conflict of interest.

G. Chad Hughes declares that he has no conflict of interest.

Lynne M. Hurwitz has received grant funding to Duke University from GEMS and Siemens Healthcare for research projects related to MDCT imaging for cardiovascular issues and related to radiation dosimetry.

J. Kevin Harrison has received research support from Medtronic and Edwards.

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Authors and Affiliations

  1. Division of Cardiology, Duke University Medical Center, Durham, NC, 27710, USA

    Sharif A. Halim, Todd L. Kiefer & J. Kevin Harrison

  2. Duke Clinical Research Institute, North Pavilion, 2400 Pratt Street, Durham, NC, 27705, USA

    Sharif A. Halim

  3. Division of Cardiac Surgery, Duke University Medical Center, Durham, NC, 27710, USA

    G. Chad Hughes

  4. Department of Radiology, Duke University Medical Center, Durham, NC, 27710, USA

    Lynne M. Hurwitz

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  1. Sharif A. Halim
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Correspondence to Sharif A. Halim.

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This article is part of the Topical Collection on Interventional Cardiology

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Halim, S.A., Kiefer, T.L., Hughes, G.C. et al. Transcatheter Aortic Valve Replacement: An Update. Curr Cardiol Rep 15, 367 (2013). https://doi.org/10.1007/s11886-013-0367-1

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