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Current Bladder Dysfunction Reports

, Volume 14, Issue 2, pp 58–66 | Cite as

Effects and Complications of Intravesical Instillation of Bacillus Calmette-Guerin Therapy

  • J. Spencer Keith
  • Mahmoud I. Khalil
  • Mohamed H. Kamel
  • Rodney Davis
  • Ehab EltahawyEmail author
Inflammatory/Infectious Bladder Disorders (MS Mourad, Section Editor)
  • 48 Downloads
Part of the following topical collections:
  1. Topical Collection on Inflammatory/Infectious Bladder Disorders

Abstract

Purpose of Review

This review will address the current literature available regarding complications after intravesical Bacillus Calmette-Guerin (BCG) therapy for bladder cancer. Topics include intravesical BCG therapy–related complications, role of BCG therapy in immunosuppression, and future directions in the context of BCG-related complications.

Recent Findings

There are several new reviews and case reports discussing unique complications following intravesical BCG therapy that should raise awareness of possible short-term and long-term effects after using this common treatment modality in bladder cancer patients.

Summary

Since intravesical BCG is a common treatment option for non-muscle invasive bladder cancer and can cause a variety of complications, it is important to recognize this aspect of the patient’s history when evaluating patients who present with symptoms similar to the ones discussed in this review. This will allow for prompt delivery of treatment as well as preventing unnecessary morbidity and mortality.

Keywords

Intravesical Bacillus Calmette-Guerin therapy BCG Non-muscle invasive bladder cancer Immunosuppression BCG complications 

Abbreviations

AFB

Acid-fast bacilli

AKI

Acute kidney injury

Anti-TB

Anti-tuberculosis

BCG

Bacillus Calmette-Guerin

CIS

Carcinoma in situ

CKD

Chronic kidney disease

INH

Isoniazid

LFTs

Liver function tests

LUTs

Lower urinary tract symptoms

MSK

Musculoskeletal

NMIBC

Non-muscle invasive bladder cancer

NSAIDs

Non-steroidal anti-inflammatory drugs

RIF

Rifampin

TUR

Transurethral resection

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • J. Spencer Keith
    • 1
  • Mahmoud I. Khalil
    • 1
  • Mohamed H. Kamel
    • 1
  • Rodney Davis
    • 1
  • Ehab Eltahawy
    • 1
    Email author
  1. 1.Department of UrologyUniversity of Arkansas for Medical SciencesLittle RockUSA

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