Skip to main content

Advertisement

Log in

Urinary Diversion for Incontinence and Voiding Dysfunction in Cancer Survivors: a Critical Review of the Literature

  • Cancer-Associated Voiding Dysfunction (A Peterson, Section Editor)
  • Published:
Current Bladder Dysfunction Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Urinary diversion (UD) remains the last option for improving quality of life in patients with treatment-refractory urinary incontinence (UI) or voiding dysfunction after cancer treatment. We aim to critically review the utility of UD for UI and voiding dysfunction in patients previously treated for malignancy.

Recent Findings

UD patients are at high risk given their oncologic treatment and multiple procedures prior to UD. The severe impact of UI and voiding dysfunction on quality of life is significant. Despite the risk of complications after UD, men reported significant improvement of their urinary symptoms and were confident that they would have sought UD sooner.

Summary

UD remains a last option for some men dealing with severe urinary symptoms after treatment of pelvic malignancy in both men and women. Further investigation is needed to better characterize the burden of disease and potential gains surrounding management of these men.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Marks LB, Carroll PR, Dugan TC, Anscher MS. The response of the urinary bladder, urethra, and ureter to radiation and chemotherapy. Radiation Oncology Biology Elsevier. 1995;31(5):1257–80.

    Article  CAS  Google Scholar 

  2. Eswara JR, Raup VT, Heningburg AM, Brandes SB. Pelvic radiation is associated with urinary fistulae repair failure and need for permanent urinary diversion. Urology. Elsevier. 2015;85(4):932–6.

    Article  Google Scholar 

  3. Anderson KM, Higuchi TT, Flynn BJ. Management of the devastated posterior urethra and bladder neck: refractory incontinence and stenosis. Translational Andrology and Urology Denver. 2015;5(1):1–6.

    Google Scholar 

  4. Hussein Al Awamlh Al B, Lee DJ, Nguyen DP, Green DA, Shariat SF, Scherr DS. Assessment of the quality-of-life and functional outcomes in patients undergoing cystectomy and urinary diversion for the management of radiation-induced refractory benign disease. Urology. 2015;85(2):394–401.

    Article  Google Scholar 

  5. Jacobs A. Indications for diversion of the urinary stream. JAMA. 1969;207:1–2.

    Article  Google Scholar 

  6. • Abrams P, Chapple C, Khoury S, Roehrborn C, de la Rosette J. Evaluation and treatment of lower urinary tract symptoms in older men. Journal of Urology Elsevier Inc. 2013;189(1):S93–S101. This article was published as a compilation of recommendations from the 6th International Consultation on New Developments in Prostate Cancer and Prostate Diseases on the management of lower urinary tract symptoms

    CAS  Google Scholar 

  7. Brown ET, Osborn D, Mock S, Ni S, Graves AJ, Milam L, et al. Temporal trends in conduit urinary diversion with concomitant cystectomy for benign indications: a population-based analysis. Urology Elsevier. 2016;98:70–4.

    Article  Google Scholar 

  8. Faris SF, Milam DF, Dmochowski RR, Kaufman MR. Reconstructive urology urinary diversions after radiation for prostate cancer: indications and treatment. Urology Elsevier Inc. 2014;84(3):702–6.

    Google Scholar 

  9. Mayer EN, Tward JD, Bassett M, Lenherr SM, Hotaling JM, Brant WO, et al. Management of Radiation Therapy Oncology Group grade 4 urinary adverse events after radiotherapy for prostate cancer. BJU Int. 2016;1–9

  10. Chrouser KL, Leibovich BC, Sweat SD, Larson DW, Davis BJ, Tran NV, et al. Urinary fistulas following external radiation or permanent brachytherapy for the treatment of prostate cancer. Journal of Urology Elsevier. 2005;173(6):1953–7.

    Article  Google Scholar 

  11. Raup VT, Eswara JR, Geminiani J, Madison K, Heningburg AM, Brandes SB. Gracilis muscle interposition flap repair of urinary fistulae: pelvic radiation is associated with persistent urinary incontinence and decreased quality of life. World J Urol. 2016;34(1):131–6.

    Article  PubMed  Google Scholar 

  12. Cohn JA, Large MC, Richards KA, Steinberg GD, Bales GT. Cystectomy and urinary diversion as management of treatment-refractory benign disease: the impact of preoperative urological conditions on perioperative outcomes. Int J Urol. 2014;21(4):382–6.

    Article  PubMed  Google Scholar 

  13. Shimko MS, Tollefson MK, Umbreit EC, Farmer SA, Blute ML, Frank I. Long-term complications of conduit urinary diversion. The Journal of Urology. Elsevier. 2011;185(2):562–7.

    Article  Google Scholar 

  14. Monn MF, Kaimakliotis HZ, Cary KC, Pedrosa JA, Flack CK, Koch MO, et al. Short-term morbidity and mortality of Indiana pouch, ileal conduit, and neobladder urinary diversion following radical cystectomy. Urol Oncol. 2014;32(8):1151–7.

    Article  PubMed  Google Scholar 

  15. Hautmann RE. Urinary diversion: ileal conduit to neobladder. J Urol. 2003;169(3):834–42.

    Article  PubMed  Google Scholar 

  16. Somani BK, Gimlin D, Fayers P, N'Dow J. Quality of life and body image for bladder cancer patients undergoing radical cystectomy and urinary diversion—a prospective cohort study with a systematic review of literature. Urology. 2009;74(5):1138–43.

    Article  PubMed  Google Scholar 

  17. •• Sack BS, Langenstroer P, Guralnick ML, Jacobson KM, OConnor C. Cystectomy and urinary diversion for the management of a devastated lower urinary tract following prostatic cryotherapy and/or radiotherapy. WMJ. 2016;115(2):1–5. This was one of the largest studies evaluating the utility of urinary diversion for urinary adverse events after prostate radiation, compiling data from 9 institutions participating in the Trauma and Urologic Reconstruction Network of Surgeons and Neurogenic Bladder Research Group

    Google Scholar 

  18. Bassett MR, Santiago-Lastra Y, Stoffel JT, Goldfarb R, Elliott SP, Pate SC, et al. Urinary diversion for severe urinary adverse events of prostate radiation: results from a multi-institutional study. The Journal of Urology Elsevier Ltd. 2016;1–18

  19. Russo P, Ravindran B, Katz J, Paty P, Guillem J, Cohen AM. Urinary diversion after total pelvic exenteration for rectal cancer. Ann Surg Oncol Springer-Verlag. 1999;6(8):732–8.

    Article  CAS  Google Scholar 

  20. Nazmy M, Yuh B, Kawachi M, Lau CS, Linehan J, Ruel NH, et al. Early and late complications of robot-assisted radical cystectomy: a standardized analysis by urinary diversion type. The Journal of Urology Elsevier. 2014;191(3):681–7.

    Article  Google Scholar 

  21. Cano Megías M, Golmayo Muñoz Delgado E. Bone and metabolic complications of urinary diversions. Endocrinología y Nutrición (English Edition). 2015;62(2):100–5.

    Google Scholar 

  22. Gruberg L, Weissman NJ, Waksman R, Fuchs S, Deible R, Pinnow EE, et al. The impact of obesity on the short-term and long-term outcomes after percutaneous coronary intervention: the obesity paradox? J Am Coll Cardiol. 2002;39(4):578–84.

    Article  PubMed  Google Scholar 

  23. Nieuwenhuijzen JA, de Vries RR, Bex A, van der Poel HG, Meinhardt W, Antonini N, et al. Urinary diversions after cystectomy: the association of clinical factors, complications and functional results of four different diversions. Eur Urol. 2008;53(4):834–44.

    Article  PubMed  Google Scholar 

  24. Huang EY-H, Skinner EC, Boyd SD, Cai J, Miranda G, Daneshmand S. Radical cystectomy with orthotopic neobladder reconstruction following prior radical prostatectomy. World J Urol. 2012;30(6):741–5.

    Article  PubMed  Google Scholar 

  25. •• Urh A, Soliman PT, Schmeler KM, Westin S, Frumovitz M, Nick AM, et al. Postoperative outcomes after continent versus incontinent urinary diversion at the time of pelvic exenteration for gynecologic malignancies. Gynecologic Oncology Elsevier. 2013;129(3):580–5. This is one of the first articles to offer an algorithm of treatment for this patient population

    Article  Google Scholar 

  26. Bailey GC, Blackburne A, Ziegelmann MJ, Lightner DJ. Outcomes of surgical management in patients with stress urinary incontinence and/or neovesicovaginal fistula after orthotopic neobladder diversion. Journal of Urology Elsevier Ltd. 2016;196(5):1478–83.

    Article  Google Scholar 

  27. Witjes JA, Compérat E, Cowan NC, De Santis M, Gakis G, Lebret T, et al. EAU guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2013 guidelines. Eur Urol European Association of Urology. 2014;65(4):778–92.

    Article  Google Scholar 

  28. PORTER M, PENSON D. Health related quality of life after radical cystectomy and urinary diversion for bladder cancer: a systematic review and critical analysis of the literature. J Urol. 2005;173(4):1318–22.

    Article  PubMed  Google Scholar 

  29. Autorino R, Quarto G, Di Lorenzo G, De Sio M, Perdonà S, Giannarini G, et al. Health related quality of life after radical cystectomy: comparison of ileal conduit to continent orthotopic neobladder. European Journal of Surgical Oncology (EJSO). 2009;35(8):858–64.

    Article  CAS  Google Scholar 

  30. Cerruto MA, D'Elia C, Siracusano S, Gedeshi X, Mariotto A, Iafrate M, et al. Systematic review and meta-analysis of non RCT's on health related quality of life after radical cystectomy using validated questionnaires: better results with orthotopic neobladder versus ileal conduit. Eur J Surg Oncol. 2016;42(3):343–60.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Benjamin N. Breyer.

Ethics declarations

Conflict of Interest

Drs Washington, Murphy, Awad, Gaither, and Breyer declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).

Additional information

This article is part of the Topical Collection on Cancer-Associated Voiding Dysfunction

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Washington, S.L., Murphy, G.P., Awad, M. et al. Urinary Diversion for Incontinence and Voiding Dysfunction in Cancer Survivors: a Critical Review of the Literature. Curr Bladder Dysfunct Rep 12, 167–173 (2017). https://doi.org/10.1007/s11884-017-0415-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11884-017-0415-6

Keywords

Navigation