Cardiometabolic Effects of Anti-obesity Pharmacotherapy
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Purpose of Review
We review recent studies discussing the impact of pharmacologic agents for weight loss on clinical cardiovascular events, as well as cardiometabolic risk factors.
Pharmacotherapy with current FDA-approved medications for weight loss can significantly improve known risk factors for the development of cardiovascular disease such as hypertension, hyperlipidemia, insulin resistance, inflammatory biomarkers, and the quantity of visceral fat, as well as non-alcoholic fatty liver disease. However, data regarding the actual reduction in clinical cardiovascular events with the use of weight loss medications is scarce.
Pharmacotherapy for weight loss may have additional benefit in optimizing patient’s cardiometabolic comorbidities and improving their clinical cardiovascular outcomes, but each drug should be carefully selected based upon individual patient characteristics.
KeywordsObesity Metabolic syndrome Weight loss medications Heart disease
The authors thank Megin Myers, CRNP, for her critical review of the manuscript.
Compliance with Ethical Standards
Conflict of Interest
NA has consulted for Novo Nordisk. AA has consulted for Novo Nordisk and is a consultant for Andrew Technologies. ARC declares no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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