Skip to main content

Advertisement

Log in

Diagnostic Error in Stroke—Reasons and Proposed Solutions

  • Cardiovascular Disease and Stroke (S. Prabhakaran, Section Editor)
  • Published:
Current Atherosclerosis Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

We discuss the frequency of stroke misdiagnosis and identify subgroups of stroke at high risk for specific diagnostic errors. In addition, we review common reasons for misdiagnosis and propose solutions to decrease error.

Recent Findings

According to a recent report by the National Academy of Medicine, most people in the USA are likely to experience a diagnostic error during their lifetimes. Nearly half of such errors result in serious disability and death. Stroke misdiagnosis is a major health care concern, with initial misdiagnosis estimated to occur in 9% of all stroke patients in the emergency setting. Under- or missed diagnosis (false negative) of stroke can result in adverse patient outcomes due to the preclusion of acute treatments and failure to initiate secondary prevention strategies. On the other hand, the overdiagnosis of stroke can result in inappropriate treatment, delayed identification of actual underlying disease, and increased health care costs. Young patients, women, minorities, and patients presenting with non-specific, transient, or posterior circulation stroke symptoms are at increased risk of misdiagnosis. Strategies to decrease diagnostic error in stroke have largely focused on early stroke detection via bedside examination strategies and a clinical decision rules. Targeted interventions to improve the diagnostic accuracy of stroke diagnosis among high-risk groups as well as symptom-specific clinical decision supports are needed.

Summary

There are a number of open questions in the study of stroke misdiagnosis. To improve patient outcomes, existing strategies to improve stroke diagnostic accuracy should be more broadly adopted and novel interventions devised and tested to reduce diagnostic errors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Singh H, Giardina TD, Meyer AND, Forjuoh SN, Reis MD, Thomas EJ. Types and origins of diagnostic errors in primary care settings. JAMA Intern Med. 2013;173(6):418–25. https://doi.org/10.1001/jamainternmed.2013.2777.

    Article  PubMed  PubMed Central  Google Scholar 

  2. •• Medicine I.o., E. National Academies of Sciences, and Medicine, Improving diagnosis in health care, ed. E.P. Balogh, B.T. Miller, and J.R. Ball. 2015, Washington, DC: The National Academies Press. 472. Detailed report regarding what is known about diagnostic error in medicine, methods to improve diagnostic safety in healthcare and suggested new research directions.

  3. Newman-Toker DE, Pronovost PJ. Diagnostic errors—the next frontier for patient safety. JAMA. 2009;301(10):1060–2. https://doi.org/10.1001/jama.2009.249.

    Article  CAS  PubMed  Google Scholar 

  4. Saber Tehrani AS, et al., 25-Year summary of US malpractice claims for diagnostic errors 1986–2010: an analysis from the National Practitioner Data Bank. BMJ Qual Saf, 2013. 22(8): p. 672 80.

  5. Jauch EC, Saver JL, Adams HP Jr, Bruno A, Connors JJ, Demaerschalk BM, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(3):870–947. https://doi.org/10.1161/STR.0b013e318284056a.

    Article  PubMed  Google Scholar 

  6. Kuruvilla A, Bhattacharya P, Rajamani K, Chaturvedi S. Factors associated with misdiagnosis of acute stroke in young adults. J Stroke Cerebrovasc Dis. 2011;20(6):523–7. https://doi.org/10.1016/j.jstrokecerebrovasdis.2010.03.005.

    Article  PubMed  Google Scholar 

  7. Edlow JA, Newman-Toker DE, Savitz SI. Diagnosis and initial management of cerebellar infarction. Lancet Neurol. 2008;7(10):951–64. https://doi.org/10.1016/S1474-4422(08)70216-3.

    Article  PubMed  Google Scholar 

  8. • Richoz B, et al. Acute stroke chameleons in a university hospital: Risk factors, circumstances, and outcomes. Neurology. 2015;85(6):505–11. Author reported 2.1% (47 out of 2200) missed ischemic stroke rate using prospective stroke registry. Stroke chameleons presented with milder stroke and fewer focal stroke signs compared to accurately diagnosed stroke patients. Cerebellar strokes had higher disability and mortality rates at 12 months.

    Article  PubMed  Google Scholar 

  9. Graber ML, Franklin N, Gordon R. Diagnostic error in internal medicine. Arch Intern Med. 2005;165(13):1493–9. https://doi.org/10.1001/archinte.165.13.1493.

    Article  PubMed  Google Scholar 

  10. Singh H, Meyer AN, Thomas EJ. The frequency of diagnostic errors in outpatient care: estimations from three large observational studies involving US adult populations. BMJ Qual Saf. 2014;23(9):727–31. https://doi.org/10.1136/bmjqs-2013-002627.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Schiff GD, Hasan O, Kim S, Abrams R, Cosby K, Lambert BL, et al. Diagnostic error in medicine: analysis of 583 physician-reported errors. Arch Intern Med. 2009;169(20):1881–7. https://doi.org/10.1001/archinternmed.2009.333.

    Article  PubMed  Google Scholar 

  12. • Tsivgoulis G, et al. Safety of intravenous thrombolysis in stroke mimics: prospective 5-year study and comprehensive meta-analysis. Stroke. 2015;46(5):1281–7. Meta-analysis of nine studies showing rates of symptomatic intracerebral hemorrhage of 0.5% among 392 stroke mimics treated with intravenous thrombolytic, significantly lower risk than in patients with acute ischemic stroke (risk ratio = 0.33; 95% confidence interval 0.14–0.77; P= 0.010).

    Article  CAS  PubMed  Google Scholar 

  13. Boudreau DM, Guzauskas GF, Chen E, Lalla D, Tayama D, Fagan SC, et al. Cost-effectiveness of recombinant tissue-type plasminogen activator within 3 hours of acute ischemic stroke: current evidence. Stroke. 2014;45(10):3032–9. https://doi.org/10.1161/STROKEAHA.114.005852.

    Article  PubMed  Google Scholar 

  14. Fagan SC, Morgenstern LB, Petitta A, Ward RE, Tilley BC, Marler JR, et al. Cost-effectiveness of tissue plasminogen activator for acute ischemic stroke. NINDS rt-PA stroke study group. Neurology. 1998;50(4):883–90. https://doi.org/10.1212/WNL.50.4.883.

    Article  CAS  PubMed  Google Scholar 

  15. •• Newman-Toker DE, et al. Missed diagnosis of stroke in the emergency department: a cross-sectional analysis of a large population-based sample. Diagnosis (Berl). 2014;1(2):155–66. Author reported 12.7% of potential missed stroke diagnoses and 1.2% of probable missed diagnoses using a multistate administrative data collection.

    Google Scholar 

  16. •• Madsen TE, et al. potentially missed diagnosis of ischemic stroke in the emergency department in the Greater Cincinnati/Northern Kentucky Stroke Study. Acad Emerg Med. 2016;23(10):1128–35. A large retrospective population-based study of stroke patients with reported 14% patients initially missed in the ED.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Libman RB, Wirkowski E, Alvir J, Rao TH. Conditions that mimic stroke in the emergency department. Implications for acute stroke trials. Arch Neurol. 1995;52(11):1119–22. https://doi.org/10.1001/archneur.1995.00540350113023.

    Article  CAS  PubMed  Google Scholar 

  18. Burton TM, Luby M, Nadareishvili Z, Benson RT, Lynch JK, Latour LL, et al. Effects of increasing IV tPA-treated stroke mimic rates at CT-based centers on clinical outcomes. Neurology. 2017;89(4):343–8. https://doi.org/10.1212/WNL.0000000000004149.

    Article  PubMed  Google Scholar 

  19. Zinkstok SM, Engelter ST, Gensicke H, Lyrer PA, Ringleb PA, Artto V, et al. Safety of thrombolysis in stroke mimics: results from a multicenter cohort study. Stroke. 2013;44(4):1080–4. https://doi.org/10.1161/STROKEAHA.111.000126.

    Article  PubMed  Google Scholar 

  20. Demaerschalk BM, Kleindorfer DO, Adeoye OM, Demchuk AM, Fugate JE, Grotta JC, et al. Scientific rationale for the inclusion and exclusion criteria for intravenous alteplase in acute ischemic stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2016;47(2):581–641. https://doi.org/10.1161/STR.0000000000000086.

    Article  PubMed  Google Scholar 

  21. Henriksen K, et al. Challenges and opportunities from the Agency for Healthcare Research and Quality (AHRQ) research summit on improving diagnosis: a proceedings review. Diagnosis, 2017. [Epub ahead of print].

  22. Shojania, K.G., et al., The autopsy as an outcome and performance measure. Evid Rep Technol Assess (Summ), 2002(58): p. 1–5.

  23. Shojania KG, Burton EC, McDonald KM, Goldman L. Changes in rates of autopsy-detected diagnostic errors over time: a systematic review. JAMA. 2003;289(21):2849–56. https://doi.org/10.1001/jama.289.21.2849.

    Article  PubMed  Google Scholar 

  24. Winters B, Custer J, Galvagno SM Jr, Colantuoni E, Kapoor SG, Lee HW, et al. Diagnostic errors in the intensive care unit: a systematic review of autopsy studies. BMJ Qual Saf. 2012;21(11):894–902. https://doi.org/10.1136/bmjqs-2012-000803.

    Article  PubMed  Google Scholar 

  25. Newman-Toker DE. A unified conceptual model for diagnostic errors: underdiagnosis, overdiagnosis, and misdiagnosis. Diagnosis (Berl). 2014;1(1):43–8. https://doi.org/10.1515/dx-2013-0027.

    Google Scholar 

  26. Ferro JM, Falcao I, Rodrigues G, Canhao P, Melo TP, Oliveira V, et al. Diagnosis of transient ischemic attack by the nonneurologist. A validation study. Stroke. 1996;27(12):2225–9. https://doi.org/10.1161/01.STR.27.12.2225.

    Article  CAS  PubMed  Google Scholar 

  27. Ferro JM, Pinto AN, Falcao I, Rodrigues G, Ferreira J, Falcao F, et al. Diagnosis of stroke by the nonneurologist. A validation study. Stroke. 1998;29(6):1106–9. https://doi.org/10.1161/01.STR.29.6.1106.

    Article  CAS  PubMed  Google Scholar 

  28. Balucani C, Bianchi R, Feldmann E, Weedon J, Kolychev D, Levine SR. To treat or not to treat? Pilot survey for minor and rapidly improving stroke. Stroke. 2015;46(3):874–6. https://doi.org/10.1161/STROKEAHA.114.008290.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Shamy MC, Jaigobin CS. The complexities of acute stroke decision-making: a survey of neurologists. Neurology. 2013;81(13):1130–3. https://doi.org/10.1212/WNL.0b013e3182a55ec7.

    Article  PubMed  Google Scholar 

  30. Peabody JW, Luck J, Jain S, Bertenthal D, Glassman P. Assessing the accuracy of administrative data in health information systems. Med Care. 2004;42(11):1066–72. https://doi.org/10.1097/00005650-200411000-00005.

    Article  PubMed  Google Scholar 

  31. Kowalski RG, Claassen J, Kreiter KT, Bates JE, Ostapkovich ND, Connolly ES, et al. Initial misdiagnosis and outcome after subarachnoid hemorrhage. JAMA. 2004;291(7):866–9. https://doi.org/10.1001/jama.291.7.866.

    Article  CAS  PubMed  Google Scholar 

  32. Lever NM, Nyström KV, Schindler JL, Halliday J, Wira C III, Funk M. Missed opportunities for recognition of ischemic stroke in the emergency department. J Emerg Nurs. 2013;39(5):434–9. https://doi.org/10.1016/j.jen.2012.02.011.

  33. Arch AE, Weisman DC, Coca S, Nystrom KV, Wira CR III, Schindler JL. Missed ischemic stroke diagnosis in the emergency department by emergency medicine and neurology services. Stroke. 2016;47(3):668–73. https://doi.org/10.1161/STROKEAHA.115.010613.

  34. Gioia LC, Zewude RT, Kate MP, Liss K, Rowe BH, Buck B, et al. Prehospital systolic blood pressure is higher in acute stroke compared with stroke mimics. Neurology. 2016;86(23):2146–53. https://doi.org/10.1212/WNL.0000000000002747.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Shenvi EC, El-Kareh R. Clinical criteria to screen for inpatient diagnostic errors: a scoping review. Diagnosis (Berl). 2015;2(1):3–19. https://doi.org/10.1515/dx-2014-0047.

    Google Scholar 

  36. Newman-Toker DE. Charted records of dizzy patients suggest emergency physicians emphasize symptom quality in diagnostic assessment. Ann Emerg Med. 2007;50(2):204–5. https://doi.org/10.1016/j.annemergmed.2007.03.037.

    Article  PubMed  Google Scholar 

  37. Kerber KA, Morgenstern LB, Meurer WJ, McLaughlin T, Hall PA, Forman J, et al. Nystagmus assessments documented by emergency physicians in acute dizziness presentations: a target for decision support? Acad Emerg Med. 2011;18(6):619–26. https://doi.org/10.1111/j.1553-2712.2011.01093.x.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Morgenstern LB, Lisabeth LD, Mecozzi AC, Smith MA, Longwell PJ, McFarling DA, et al. A population-based study of acute stroke and TIA diagnosis. Neurology. 2004;62(6):895–900. https://doi.org/10.1212/01.WNL.0000115103.49326.5E.

    Article  CAS  PubMed  Google Scholar 

  39. Kerber KA, Brown DL, Lisabeth LD, Smith MA, Morgenstern LB. Stroke among patients with dizziness, vertigo, and imbalance in the emergency department: a population-based study. Stroke. 2006;37(10):2484–7. https://doi.org/10.1161/01.STR.0000240329.48263.0d.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Atzema CL, Grewal K, Lu H, Kapral MK, Kulkarni G, Austin PC. Outcomes among patients discharged from the emergency department with a diagnosis of peripheral vertigo. Ann Neurol. 2016;79(1):32–41. https://doi.org/10.1002/ana.24521.

    Article  PubMed  Google Scholar 

  41. Wendt M, Ebinger M, Kunz A, Rozanski M, Waldschmidt C, Weber JE, et al. Copeptin levels in patients with acute ischemic stroke and stroke mimics. Stroke. 2015;46(9):2426–31. https://doi.org/10.1161/STROKEAHA.115.009877.

    Article  CAS  PubMed  Google Scholar 

  42. Beam CA, Layde PM, Sullivan DC. Variability in the interpretation of screening mammograms by US radiologists. Findings from a national sample. Arch Intern Med. 1996;156(2):209–13. https://doi.org/10.1001/archinte.1996.00440020119016.

    Article  CAS  PubMed  Google Scholar 

  43. Raab SS. Variability of practice in anatomic pathology and its effect on patient outcomes. Semin Diagn Pathol. 2005;22(2):177–85. https://doi.org/10.1053/j.semdp.2006.01.004.

    Article  PubMed  Google Scholar 

  44. Kattah JC, Talkad AV, Wang DZ, Hsieh YH, Newman-Toker DE. HINTS to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging. Stroke. 2009;40(11):3504–10. https://doi.org/10.1161/STROKEAHA.109.551234.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Gandhi TK, Kachalia A, Thomas EJ, Puopolo AL, Yoon C, Brennan TA, et al. Missed and delayed diagnoses in the ambulatory setting: a study of closed malpractice claims. Ann Intern Med. 2006;145(7):488–96. https://doi.org/10.7326/0003-4819-145-7-200610030-00006.

    Article  PubMed  Google Scholar 

  46. Kachalia A, Gandhi TK, Puopolo AL, Yoon C, Thomas EJ, Griffey R, et al. Missed and delayed diagnoses in the emergency department: a study of closed malpractice claims from 4 liability insurers. Ann Emerg Med. 2007;49(2):196–205. https://doi.org/10.1016/j.annemergmed.2006.06.035.

    Article  PubMed  Google Scholar 

  47. Troxel DB, Doctor’s company Diagnostic error in medical practice by specialty 2014. accessed September, 1 2017 2017.

  48. Vermeulen MJ, Schull MJ. Missed diagnosis of subarachnoid hemorrhage in the emergency department. Stroke. 2007;38(4):1216–21. https://doi.org/10.1161/01.STR.0000259661.05525.9a.

    Article  PubMed  Google Scholar 

  49. Fahimi J, Navi BB, Kamel H. Potential misdiagnoses of Bell’s palsy in the emergency department. Ann Emerg Med. 2014;63(4):428–34. https://doi.org/10.1016/j.annemergmed.2013.06.022.

    Article  PubMed  Google Scholar 

  50. Cartwright DJ. ICD-9-CM to ICD-10-CM codes: what? Why? How? Adv Wound Care (New Rochelle). 2013;2(10):588–92. https://doi.org/10.1089/wound.2013.0478.

    Article  Google Scholar 

  51. Murphy DR, Laxmisan A, Reis BA, Thomas EJ, Esquivel A, Forjuoh SN, et al. Electronic health record-based triggers to detect potential delays in cancer diagnosis. BMJ Qual Saf. 2014;23(1):8–16. https://doi.org/10.1136/bmjqs-2013-001874.

    Article  PubMed  Google Scholar 

  52. Murphy DR, Wu L, Thomas EJ, Forjuoh SN, Meyer AND, Singh H. Electronic trigger-based intervention to reduce delays in diagnostic evaluation for cancer: a cluster randomized controlled trial. J Clin Oncol. 2015;33(31):3560–7. https://doi.org/10.1200/JCO.2015.61.1301.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Singh H, Giardina TD, Forjuoh SN, Reis MD, Kosmach S, Khan MM, et al. Electronic health record-based surveillance of diagnostic errors in primary care. BMJ Qual Saf. 2012;21(2):93–100. https://doi.org/10.1136/bmjqs-2011-000304.

    Article  PubMed  Google Scholar 

  54. Al-Mutairi A, Meyer AND, Thomas EJ, Etchegaray JM, Roy KM, Davalos MC, et al. Accuracy of the Safer Dx instrument to identify diagnostic errors in primary care. J Gen Intern Med. 2016;31(6):602–8. https://doi.org/10.1007/s11606-016-3601-x.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Hudspeth J, El-Kareh R, Schiff G. Use of an expedited review tool to screen for prior diagnostic error in emergency department patients. Appl Clin Inform. 2015;6(4):619–28. https://doi.org/10.4338/ACI-2015-04-RA-0042.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Wears RL, Nemeth CP. Replacing hindsight with insight: toward better understanding of diagnostic failures. Ann Emerg Med. 2007;49(2):206–9. https://doi.org/10.1016/j.annemergmed.2006.08.027.

    Article  PubMed  Google Scholar 

  57. Kim AS, Moffatt E, Ursell PC, Devinsky O, Olgin J, Tseng ZH. Sudden neurologic death masquerading as out-of-hospital sudden cardiac death. Neurology. 2016;87(16):1669–73. https://doi.org/10.1212/WNL.0000000000003238.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Obermeyer Z, et al. Early death after discharge from emergency departments: analysis of national US insurance claims data. BMJ. 2017;356:j239.

    Article  PubMed  Google Scholar 

  59. •• Tarnutzer, A.A., et al., ED misdiagnosis of cerebrovascular events in the era of modern neuroimaging: a meta-analysis. Neurology, 2017. 88(15): p. 1468–1477. Recent meta-analysis of 23 studies including 15,721 patients eventually diagnosed with ischemic stroke, subarachnoid hemorrhage, and transient ischemic attack, with 8.7% of overall reported rate of stroke misdiagnosis.

  60. Dupre CM, Libman R, Dupre SI, Katz JM, Rybinnik I, Kwiatkowski T. Stroke chameleons. J Stroke Cerebrovasc Dis. 2014;23(2):374–8. https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.07.015.

    Article  PubMed  Google Scholar 

  61. Merino JG, Luby M, Benson RT, Davis LA, Hsia AW, Latour LL, et al. Predictors of acute stroke mimics in 8187 patients referred to a stroke service. J Stroke Cerebrovasc Dis. 2013;22(8):e397–403. https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.04.018.

    Article  PubMed  Google Scholar 

  62. El Husseini N, Goldstein LB. “Code stroke”: hospitalized versus emergency department patients. J Stroke Cerebrovasc Dis. 2013;22(4):345–8. https://doi.org/10.1016/j.jstrokecerebrovasdis.2011.09.012.

    Article  PubMed  Google Scholar 

  63. Vannemreddy P, et al. Delayed diagnosis of intracranial aneurysms: confounding factors in clinical presentation and the influence of misdiagnosis on outcome. South Med J. 2001;94(11):1108–11. https://doi.org/10.1097/00007611-200111000-00014.

    Article  CAS  PubMed  Google Scholar 

  64. Edlow JA, Caplan LR. Avoiding pitfalls in the diagnosis of subarachnoid hemorrhage. N Engl J Med. 2000;342(1):29–36. https://doi.org/10.1056/NEJM200001063420106.

    Article  CAS  PubMed  Google Scholar 

  65. Chalela JA, Kidwell CS, Nentwich LM, Luby M, Butman JA, Demchuk AM, et al. Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison. Lancet. 2007;369(9558):293–8. https://doi.org/10.1016/S0140-6736(07)60151-2.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Hemphill, J.C., 3rd, M. Farrant, and T.A. Neill, Jr., Prospective validation of the ICH Score for 12-month functional outcome. Neurology, 2009. 73(14): p. 1088–1094, DOI: https://doi.org/10.1212/WNL.0b013e3181b8b332.

  67. Castle J, Mlynash M, Lee K, Caulfield AF, Wolford C, Kemp S, et al. Agreement regarding diagnosis of transient ischemic attack fairly low among stroke-trained neurologists. Stroke. 2010;41(7):1367–70. https://doi.org/10.1161/STROKEAHA.109.577650.

    Article  PubMed  Google Scholar 

  68. Easton, J.D., et al., Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease. The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists. Stroke, 2009. 40(6): p. 2276-93.

  69. Lisabeth LD, Brown DL, Hughes R, Majersik JJ, Morgenstern LB. Acute stroke symptoms: comparing women and men. Stroke. 2009;40(6):2031–6. https://doi.org/10.1161/STROKEAHA.109.546812.

    Article  PubMed  Google Scholar 

  70. Labiche LA, Chan W, Saldin KR, Morgenstern LB. Sex and acute stroke presentation. Ann Emerg Med. 2002;40(5):453–60. https://doi.org/10.1067/mem.2002.128682.

    Article  PubMed  Google Scholar 

  71. Gargano JW, Wehner S, Reeves MJ. Do presenting symptoms explain sex differences in emergency department delays among patients with acute stroke? Stroke. 2009;40(4):1114–20. https://doi.org/10.1161/STROKEAHA.108.543116.

    Article  PubMed  Google Scholar 

  72. Jungehulsing GJ, Rossnagel K, Nolte CH, Muller-Nordhorn J, Roll S, Klein M, et al. Emergency department delays in acute stroke—analysis of time between ED arrival and imaging. Eur J Neurol. 2006;13(3):225–32. https://doi.org/10.1111/j.1468-1331.2006.01170.x.

    Article  CAS  PubMed  Google Scholar 

  73. Rose KM, Rosamond WD, Huston SL, Murphy CV, Tegeler CH. Predictors of time from hospital arrival to initial brain-imaging among suspected stroke patients: the North Carolina Collaborative Stroke Registry. Stroke. 2008;39(12):3262–7. https://doi.org/10.1161/STROKEAHA.108.524686.

    Article  PubMed  Google Scholar 

  74. Centers for Disease, C. and Prevention, Prehospital and hospital delays after stroke onset—United States, 2005–2006. MMWR Morb Mortal Wkly Rep, 2007 56(19): p. 474–478.

  75. Gargano JW, Wehner S, Reeves M. Sex differences in acute stroke care in a statewide stroke registry. Stroke. 2008;39(1):24–9. https://doi.org/10.1161/STROKEAHA.107.493262.

    Article  PubMed  Google Scholar 

  76. Schumacher HC, Bateman BT, Boden-Albala B, Berman MF, Mohr JP, Sacco RL, et al. Use of thrombolysis in acute ischemic stroke: analysis of the Nationwide Inpatient Sample 1999 to 2004. Ann Emerg Med. 2007;50(2):99–107. https://doi.org/10.1016/j.annemergmed.2007.01.021.

    Article  PubMed  Google Scholar 

  77. Reid JM, Dai D, Gubitz GJ, Kapral MK, Christian C, Phillips SJ. Gender differences in stroke examined in a 10-year cohort of patients admitted to a Canadian teaching hospital. Stroke. 2008;39(4):1090–5. https://doi.org/10.1161/STROKEAHA.107.495143.

    Article  PubMed  Google Scholar 

  78. Savitz SI, Caplan LR, Edlow JA. Pitfalls in the diagnosis of cerebellar infarction. Acad Emerg Med. 2007;14(1):63–8. https://doi.org/10.1111/j.1553-2712.2007.tb00373.x.

    Article  PubMed  Google Scholar 

  79. Brown DL, Lisabeth LD, Garcia NM, Smith MA, Morgenstern LB. Emergency department evaluation of ischemic stroke and TIA: the BASIC Project. Neurology. 2004;63(12):2250–4. https://doi.org/10.1212/01.WNL.0000147292.64051.9B.

    Article  CAS  PubMed  Google Scholar 

  80. Rostanski SK, Stillman J, Williams O, Marshall RS, Yaghi S, Willey JZ. The influence of language discordance between patient and physician on time-to-thrombolysis in acute ischemic stroke. Neurohospitalist. 2016;6(3):107–10. https://doi.org/10.1177/1941874416637405.

    Article  PubMed  PubMed Central  Google Scholar 

  81. Rostanski SK, Williams O, Stillman JI, Marshall RS, Willey JZ. Language barriers between physicians and patients are not associated with thrombolysis of stroke mimics. Neurol Clin Pract. 2016;6(5):389–96. https://doi.org/10.1212/CPJ.0000000000000287.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Cruz-Flores S, Rabinstein A, Biller J, Elkind MS, Griffith P, Gorelick PB, et al. Racial-ethnic disparities in stroke care: the American experience: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42(7):2091–116. https://doi.org/10.1161/STR.0b013e3182213e24.

    Article  PubMed  Google Scholar 

  83. Paul NL, Simoni M, Rothwell PM, Oxford Vascular Study. Transient isolated brainstem symptoms preceding posterior circulation stroke: a population-based study. Lancet Neurol. 2013;12(1):65–71. https://doi.org/10.1016/S1474-4422(12)70299-5.

    Article  PubMed  PubMed Central  Google Scholar 

  84. Tarnutzer AA, Berkowitz AL, Robinson KA, Hsieh YH, Newman-Toker DE. Does my dizzy patient have a stroke? A systematic review of bedside diagnosis in acute vestibular syndrome. CMAJ. 2011;183(9):E571–92. https://doi.org/10.1503/cmaj.100174.

    Article  PubMed  PubMed Central  Google Scholar 

  85. Newman-Toker DE, Hsieh YH, Camargo CA Jr, Pelletier AJ, Butchy GT, Edlow JA. Spectrum of dizziness visits to US emergency departments: cross-sectional analysis from a nationally representative sample. Mayo Clin Proc. 2008;83(7):765–75. https://doi.org/10.4065/83.7.765.

    Article  PubMed  PubMed Central  Google Scholar 

  86. Benbadis SR, Sila CA, Cristea RL. Mental status changes and stroke. J Stroke Cerebrovasc Dis. 1994;4(4):216–9. https://doi.org/10.1016/S1052-3057(10)80093-X.

    Article  CAS  PubMed  Google Scholar 

  87. Huff JS. Stroke mimics and chameleons. Emerg Med Clin North Am. 2002;20(3):583–95. https://doi.org/10.1016/S0733-8627(02)00012-3.

    Article  PubMed  Google Scholar 

  88. • Brandler ES, et al. Prehospital stroke identification: factors associated with diagnostic accuracy. J Stroke Cerebrovasc Dis. 2015;24(9):2161–6. Retrospective pre-hospital analysis of stroke diagnosis by EMS showed that seizure was among common symptom associated with both stroke mimics and stroke chameleons.

    Article  PubMed  Google Scholar 

  89. Shinton RA, Gill JS, Melnick SC, Gupta AK, Beevers DG. The frequency, characteristics and prognosis of epileptic seizures at the onset of stroke. J Neurol Neurosurg Psychiatry. 1988;51(2):273–6. https://doi.org/10.1136/jnnp.51.2.273.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  90. Semmlack S, Yeginsoy D, Spiegel R, Tisljar K, Rüegg S, Marsch S, et al. Emergency response to out-of-hospital status epilepticus: a 10-year observational cohort study. Neurology. 2017;89(4):376–84. https://doi.org/10.1212/WNL.0000000000004147.

    Article  PubMed  Google Scholar 

  91. Croskerry P. Clinical cognition and diagnostic error: applications of a dual process model of reasoning. Adv Health Sci Educ Theory Pract. 2009;14(Suppl 1):27–35. https://doi.org/10.1007/s10459-009-9182-2.

    Article  PubMed  Google Scholar 

  92. Liberman AL, Liotta EM, Caprio FZ, Ruff I, Maas MB, Bernstein RA, et al. Do efforts to decrease door-to-needle time risk increasing stroke mimic treatment rates? Neurol Clin Pract. 2015;5(3):247–52. https://doi.org/10.1212/CPJ.0000000000000122.

    Article  PubMed  PubMed Central  Google Scholar 

  93. Meurer WJ, Majersik JJ, Frederiksen SM, Kade AM, Sandretto AM, Scott PA. Provider perceptions of barriers to the emergency use of tPA for acute ischemic stroke: a qualitative study. BMC Emerg Med. 2011;11(1):5. https://doi.org/10.1186/1471-227X-11-5.

    Article  PubMed  PubMed Central  Google Scholar 

  94. Khatri P, Kleindorfer DO, Yeatts SD, Saver JL, Levine SR, Lyden PD, et al. Strokes with minor symptoms: an exploratory analysis of the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator trials. Stroke. 2010;41(11):2581–6. https://doi.org/10.1161/STROKEAHA.110.593632.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  95. Dhamoon MS, Moon YP, Paik MC, Boden-Albala B, Rundek T, Sacco RL, et al. Long-term functional recovery after first ischemic stroke: the Northern Manhattan Study. Stroke. 2009;40(8):2805–11. https://doi.org/10.1161/STROKEAHA.109.549576.

    Article  PubMed  PubMed Central  Google Scholar 

  96. Kohrmann M, et al. Safety and outcome after thrombolysis in stroke patients with mild symptoms. Cerebrovasc Dis. 2009;27(2):160–6. https://doi.org/10.1159/000185607.

    Article  CAS  PubMed  Google Scholar 

  97. Fischer U, Baumgartner A, Arnold M, Nedeltchev K, Gralla J, Marco de Marchis G, et al. What is a minor stroke? Stroke. 2010;41(4):661–6. https://doi.org/10.1161/STROKEAHA.109.572883.

    Article  PubMed  Google Scholar 

  98. Gerrity MS, DeVellis RF, Earp JA. Physicians’ reactions to uncertainty in patient care. A new measure and new insights. Med Care. 1990;28(8):724–36. https://doi.org/10.1097/00005650-199008000-00005.

    Article  CAS  PubMed  Google Scholar 

  99. Farnan JM, Johnson JK, Meltzer DO, Humphrey HJ, Arora VM. Resident uncertainty in clinical decision-making and impact on patient care: a qualitative study. Qual Saf Health Care. 2008;17(2):122–6. https://doi.org/10.1136/qshc.2007.023184.

    Article  CAS  PubMed  Google Scholar 

  100. Ruff IM, Liberman AL, Caprio FZ, Maas MB, Mendelson SJ, Sorond FA, et al. A resident boot camp for reducing door-to-needle times at academic medical centers. Neurol Clin Pract. 2017;7(3):237–45. https://doi.org/10.1212/CPJ.0000000000000367.

    Article  PubMed  Google Scholar 

  101. • Shamy MC, et al. How patient Demographics, imaging, and beliefs influence tissue-type plasminogen activator use: a survey of North American neurologists. Stroke. 2016;47(8):2051–7. Online survey of neurologists using a clinical vignette, demonstrated how physicians’ willingness to treat with thrombolytic increased with additional clinical data suggestive of acute stroke.

    Article  CAS  PubMed  Google Scholar 

  102. Berner ES, Graber ML. Overconfidence as a cause of diagnostic error in medicine. Am J Med. 2008;121(5 Suppl):S2–23. https://doi.org/10.1016/j.amjmed.2008.01.001.

    Article  PubMed  Google Scholar 

  103. Meyer AN, et al. Physicians’ diagnostic accuracy, confidence, and resource requests: a vignette study. JAMA Intern Med. 2013;173(21):1952–8. https://doi.org/10.1001/jamainternmed.2013.10081.

    Article  PubMed  Google Scholar 

  104. Singh H, Graber ML, Hofer TP. Measures to improve diagnostic safety in clinical practice. J Patient Saf. 2016:1. https://doi.org/10.1097/PTS.0000000000000338.

  105. Kim AS, Sidney S, Klingman JG, Johnston SC. Practice variation in neuroimaging to evaluate dizziness in the ED. Am J Emerg Med. 2012;30(5):665–72. https://doi.org/10.1016/j.ajem.2011.02.038.

    Article  PubMed  Google Scholar 

  106. • Goyal MS, et al. Streamlined hyperacute magnetic resonance imaging protocol identifies tissue-type plasminogen activator-eligible stroke patients when clinical impression is stroke mimic. Stroke. 2016;47(4):1012–7. Single-center report of the implementation of a hyperacute MRI protocol for patients within a treatment window, who were not initially thought to warrant thrombolytic treatment for neurological deficits. Seven patients, who would not have received acute thrombolytic treatments prior to the adoption of hyperacute MRI, did receive thrombolysis.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  107. Shah S, Luby M, Poole K, Morella T, Keller E, Benson RT, et al. Screening with MRI for Accurate and Rapid Stroke Treatment: SMART. Neurology. 2015;84(24):2438–44. https://doi.org/10.1212/WNL.0000000000001678.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  108. Bhattacharya P, Nagaraja N, Rajamani K, Madhavan R, Santhakumar S, Chaturvedi S. Early use of MRI improves diagnostic accuracy in young adults with stroke. J Neurol Sci. 2013;324(1–2):62–4. https://doi.org/10.1016/j.jns.2012.10.002.

    Article  PubMed  Google Scholar 

  109. Newman-Toker DE, Camargo CA Jr, Hsieh YH, Pelletier AJ, Edlow JA. Disconnect between charted vestibular diagnoses and emergency department management decisions: a cross-sectional analysis from a nationally representative sample. Acad Emerg Med. 2009;16(10):970–7. https://doi.org/10.1111/j.1553-2712.2009.00523.x.

  110. •• Goyal N, et al. FABS: an intuitive tool for screening of stroke mimics in the emergency department. Stroke. 2016;47(9):2216–20. A scoring system to help distinguish stroke mimic from true strokes. A FABS score of > 3 has shown to have 90% sensitivity and 91% specificity to identify stroke mimics with absence of facial droop being the most sensitive component.

    Article  PubMed  Google Scholar 

  111. • Ali SF, et al. The TeleStroke mimic (TM)-score: a prediction rule for identifying stroke mimics evaluated in a Telestroke Network. J Am Heart Assoc. 2014;3(3):e000838. A predictor rule to prospectively identify stroke mimics during telestroke evaluation of possible ischemic stroke. A score of ≤ 5 strongly raises suspicion for a mimic and a score of ≥ 20 strongly supports the diagnosis of stroke.

    Article  PubMed  PubMed Central  Google Scholar 

  112. Perry JJ, Stiell IG, Sivilotti MLA, Bullard MJ, Hohl CM, Sutherland J, et al. Clinical decision rules to rule out subarachnoid hemorrhage for acute headache. JAMA. 2013;310(12):1248–55. https://doi.org/10.1001/jama.2013.278018.

    Article  CAS  PubMed  Google Scholar 

  113. Newman-Toker DE, Edlow JA. High-stakes diagnostic decision rules for serious disorders: the Ottawa subarachnoid hemorrhage rule. JAMA. 2013;310(12):1237–9. https://doi.org/10.1001/jama.2013.278019.

    Article  CAS  PubMed  Google Scholar 

  114. Zwaan L, Thijs A, Wagner C, Timmermans DRM. Application of an evidence-based decision rule to patients with suspected pulmonary embolism. J Eval Clin Pract. 2013;19(4):682–8. https://doi.org/10.1111/jep.12019.

    Article  PubMed  Google Scholar 

  115. Newman-Toker DE, Edlow JA. TiTrATE: a novel, evidence-based approach to diagnosing acute dizziness and vertigo. Neurol Clin. 2015;33(3):577–99, viii. https://doi.org/10.1016/j.ncl.2015.04.011.

    Article  PubMed  PubMed Central  Google Scholar 

  116. Edlow JA. A new approach to the diagnosis of acute dizziness in adult patients. Emerg Med Clin North Am. 2016;34(4):717–42. https://doi.org/10.1016/j.emc.2016.06.004.

    Article  PubMed  Google Scholar 

  117. Newman-Toker DE, Kerber KA, Hsieh YH, Pula JH, Omron R, Saber Tehrani AS, et al. HINTS outperforms ABCD2 to screen for stroke in acute continuous vertigo and dizziness. Acad Emerg Med. 2013;20(10):986–96. https://doi.org/10.1111/acem.12223.

    Article  PubMed  Google Scholar 

  118. Saber Tehrani AS, Kattah JC, Mantokoudis G, Pula JH, Nair D, Blitz A, et al. Small strokes causing severe vertigo: frequency of false-negative MRIs and nonlacunar mechanisms. Neurology. 2014;83(2):169–73. https://doi.org/10.1212/WNL.0000000000000573.

    Article  PubMed  PubMed Central  Google Scholar 

  119. Bartl K, Lehnen N, Kohlbecher S, Schneider E. Head impulse testing using video-oculography. Ann N Y Acad Sci. 2009;1164(1):331–3. https://doi.org/10.1111/j.1749-6632.2009.03850.x.

    Article  PubMed  Google Scholar 

  120. Vuong LN, Thulasi P, Biousse V, Garza P, Wright DW, Newman NJ, et al. Ocular fundus photography of patients with focal neurologic deficits in an emergency department. Neurology. 2015;85(3):256–62. https://doi.org/10.1212/WNL.0000000000001759.

    Article  PubMed  PubMed Central  Google Scholar 

  121. Bruce BB, Lamirel C, Wright DW, Ward A, Heilpern KL, Biousse V, et al. Nonmydriatic ocular fundus photography in the emergency department. N Engl J Med. 2011;364(4):387–9. https://doi.org/10.1056/NEJMc1009733.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  122. AHRQ Research Summit on Improving Diagnosis in Health Care. Content last reviewed August 2017. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/news/events/ahrq-research-summit-diagnostic-safety.html.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ekaterina Bakradze.

Ethics declarations

Conflict of Interest

Ekaterina Bakradze and Ava L. Liberman declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Cardiovascular Disease and Stroke

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bakradze, E., Liberman, A.L. Diagnostic Error in Stroke—Reasons and Proposed Solutions. Curr Atheroscler Rep 20, 11 (2018). https://doi.org/10.1007/s11883-018-0712-3

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11883-018-0712-3

Keywords

Navigation