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Exercise-Induced Anaphylaxis: Literature Review and Recent Updates

  • Anaphylaxis and Drug Allergy (DA Khan and M Castells, Section Editors)
  • Published:
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Abstract

Purpose of Review

This paper will review the pathophysiology, diagnosis, and treatment of exercise-induced anaphylaxis and food-dependent, exercise-induced anaphylaxis with an emphasis on novel studies published in the past several years.

Recent Findings

Exercise-induced anaphylaxis (EIAn) is a clinical syndrome characterized by anaphylaxis during or shortly after physical exertion. The syndrome is broadly grouped into two categories: exercise-induced anaphylaxis and food-dependent, exercise-induced anaphylaxis (FDEIAn). Recent literature indicates that FDEIAn is a primary IgE-mediated food allergy which is augmented by several cofactors. Cofactors such as exercise, NSAIDs, and alcohol increase intestinal permeability and allow increased antigen uptake, thereby causing symptoms. The pathophysiology of EIAn is still under investigation.

Summary

EIAn and FDEIAn are rare clinical syndromes characterized by symptoms during or shortly after exercise. Despite recent advances in the understanding of EIAn and FDEIAn, the pathophysiology of both conditions is not fully understood.

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Papers of particular interest, published recently, have been highlighted as: • Of importance

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  1. Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, 60 Fenwood Rd., Building for Transformative Medicine, 5th Floor, Boston, MA, 02115, USA

    Matthew P. Giannetti

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This article is part of the Topical Collection on Anaphylaxis and Drug Allergy

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Giannetti, M.P. Exercise-Induced Anaphylaxis: Literature Review and Recent Updates. Curr Allergy Asthma Rep 18, 72 (2018). https://doi.org/10.1007/s11882-018-0830-6

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